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The protein encoded by ASB3 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. Additionally we are shipping ASB3 Antibodies (50) and many more products for this protein.
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ASB3 dysfunction resulted from gene mutations or down-regulated expression frequently exists in colorectal cancer and likely plays a key role in the pathogenesis and progression of colorectal cancer.
GWAS findings for bronchodilator response in asthmatic subjects suggest that ASB3 gene, associated with smooth muscle relaxation, may play a role in the genetics of asthma.
ASB3 is a negative regulator of TNF-R2 (show TNFRSF1B Proteins)-mediated cellular responses to TNF-alpha (show TNF Proteins) by direct targeting of TNF-R2 (show TNFRSF1B Proteins) for ubiquitination and proteasome-mediated degradation.
This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. The transcript includes exons from both GPR75 and ASB3 and translation initiates in the 5' non-coding exon of GPR75. The resulting protein has a novel N-terminus but is otherwise identical to that encoded by ASB3.
ankyrin repeat and SOCS box protein 3
, ankyrin repeat and SOCS box-containing protein 3
, ankyrin repeat-containing SOCS box protein 3
, ankyrin repeat and SOCS box-containing 3-like
, ankyrin repeat and SOCS box-containing 3
, GPR75-ASB3 protein