Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F Proteins (APOBEC3F)

APOBEC3F is a member of the cytidine deaminase gene family. Additionally we are shipping APOBEC3F Antibodies (39) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APOBEC3F 200316 Q8IUX4
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Top APOBEC3F Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days

APOBEC3F Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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More Proteins for Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F) Interaction Partners

Human Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F) interaction partners

  1. Apolipoprotein B mRNA editing enzyme catalytic subunit 3F (A3F) polymorphism A3F 231V restrict HIV-1 infection more efficiently than A3F 231 and is partially protected from Vif-mediated degradation. A3F 231V induces more mutations than A3F 231I in HIV-1 proviral DNA. A3F genotypes are commonly heterozygous. Hetero-oligomerization with A3F 231V results in partial stabilization of A3F 231I and A3G in the presence of Vif.

  2. APOBEC3DE binds to itself, APOBEC3F, and APOBEC3G and antagonizes APOBEC3F and, to a lesser extent, APOBEC3G restriction of hepatitis B virus replication.

  3. These results indicate that APOBEC3 proteins can be copackaged and can comutate the same genomes, and can cooperate to inhibit HIV replication.

  4. an APOBEC3F/APOBEC3G hetero-oligomer can form that has unique properties compared to each APOBEC3 alone. This hetero-oligomer has increased efficiency of virus hypermutation, raising the idea that we still may not fully realize the antiviral mechanisms of endogenous APOBEC3 enzymes. Hetero-oligomerization may be a mechanism to increase their antiviral activity in the presence of Vif.

  5. virus adaptation and computational studies to interrogate the APOBEC3F-Vif interface and build a robust structural model; taken together with mutagenesis results, propose a wobble model to explain how HIV-1 Vif has evolved to bind different APOBEC3 enzymes

  6. Findings support a role for APOBEC3G/F proteins in the generation of plasma drug-resistant minority human immunodeficiency virus type 1 variants (DRMVs). However, this role seems to be limited to a small subset of mutations and does not explain most of the DRMVs evaluated.

  7. Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from hepatitis b virus-hepatocellular carcinoma patients.

  8. Our results provide genetic epidemiological evidence that A3F(APOBEC3F ) modulates HIV-1/AIDS disease progression

  9. Six residues located within the conserved HIV-1 Vif F1-, F2-, and F3-box motifs are essential for both APOBEC3C and APOBEC3F degradation, and an additional four residues are uniquely required for APOBEC3F degradation.

  10. This study showed for the first time a high level of APOBEC3F/3G editing in HIV-2 sequences from antiretroviral-naive patients.

  11. APOBEC3D/F and APOBEC3G fundamentally work as restriction factors against HIV-1 in vivo

  12. APOBEC3G is more efficient at mutating retroviral DNA than APOBEC3F.

  13. A3G and A3F inhibit porcine endogenous retrovirus replication.

  14. The rather indiscriminate RNA binding characteristics of A3G and A3F promote functionality by enabling recruitment into a wide range of retroviral particles whose packaged RNA genomes comprise divergent sequences.

  15. The nucleocapsid domain of HIV-1 Gag and a linker sequence between the two cytidine deaminase domains are required for viral packaging of APOBEC3F.

  16. Authors found that one pair of leucines in each of APOBEC3F's C-terminal and N-terminal cytidine deaminase domains jointly determined the degree of localization of APOBEC3F into HIV-1 virion cores.

  17. This approach identified the alpha3 and alpha4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

  18. APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome have roles in reducing recognition by CD8+ T cells

  19. Authors found that APOBEA3G, APOBEA3F, and APOBEA3H-hapII, but not APOBEA3D, were susceptible to HIV-2 Vif-induced degradation.

  20. we demonstrate key differences in the impact of APOBEC3F- and APOBEC3G-induced mutagenesis on HIV-1

Rhesus Monkey Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3F (APOBEC3F) interaction partners

  1. APOBEC3F/G-specific responses in HIV-1-infected rhesus macaques are CD8+ T cell mediated.

  2. Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys.

  3. APOBEC3 proteins restrict xenotropic murine leukemia virus-related virus infections in a Macaca mulatta model.

APOBEC3F Protein Profile

Protein Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with APOBEC3F

  • apolipoprotein B mRNA editing enzyme catalytic subunit 3F (APOBEC3F)
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F (APOBEC3F)
  • A3F protein
  • APOBEC3F protein
  • ARP8 protein
  • BK150C2.4.MRNA protein
  • KA6 protein

Protein level used designations for APOBEC3F

DNA dC->dU-editing enzyme APOBEC-3F , apolipoprotein B mRNA editing enzyme cytidine deaminase , apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F , induced upon T-cell activation , apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F , apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3F

200316 Homo sapiens
470275 Pan troglodytes
723812 Macaca mulatta
100037691 Ovis aries
100070221 Equus caballus
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