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APOL1 encodes a secreted high density lipoprotein which binds to apolipoprotein A-I.
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Human Polyclonal APOL1 Primary Antibody for IHC, IHC (p) - ABIN4281231
Madhavan, OToole, Konieczkowski, Ganesan, Bruggeman, Sedor: APOL1 localization in normal kidney and nondiabetic kidney disease. in Journal of the American Society of Nephrology : JASN 2011
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Human Monoclonal APOL1 Primary Antibody for ELISA, WB - ABIN968963
Vanhollebeke, Nielsen, Watanabe, Truc, Vanhamme, Nakajima, Moestrup, Pays: Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 Pubmed References
Human Polyclonal APOL1 Primary Antibody for ELISA, WB - ABIN449525
Pérez-Morga, Vanhollebeke, Paturiaux-Hanocq, Nolan, Lins, Homblé, Vanhamme, Tebabi, Pays, Poelvoorde, Jacquet, Brasseur, Pays: Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. in Science (New York, N.Y.) 2005
zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin (show NPHS1 Antibodies)
In individuals at risk for nondiabetic kidney disease based on African ancestry, the majority of that risk can be explained by two variants in the APOL1 gene.
Considering APOL1 evolution also may help us understand how APOL1 risk variants cause kidney disease in modern humans.
APOL1 variants are associated with HIV-associated nephropathy(HIVAN), a podocyte disease,but not with HIV-immune complex disease, primarily a disease of the mesangium.
the associations of the APOL1 risk variants with microalbuminuria, incident CKD, and subsequent kidney function decline implicate a potential role in both the development and progression of CKD. Unlike the consistent association with CKD, the association of the APOL1 risk variants with cardiovascular disease is less clear.
The presence of two APOL1 renal risk variants in deceased donors shortens survival of their renal allografts. No study has examined the potential interaction of APOL1 genotype of the donors, deceased or living, and recipients.
expression of G1 or G2 APOL1 results in significantly more cell death compared with wild-type APOL1 (G0) in various human cells in culture
Genetic variant in apolipoprotein L1 is not associated with preterm birth in African American population.
This is the first report of a specific association of APOL1 with small vessel disease (SVD (show KCNJ13 Antibodies)) ischemic stroke.
study found strong evidence for no association with Trypanosoma brucei rhodesiense Human African trypanosomiasis and APOL1 G2 in two Ugandan populations
APOL1 variants are not associated with longitudinal blood pressure in blacks.
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.