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APOL1 encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Additionally we are shipping APOL1 Kits (28) and APOL1 Proteins (5) and many more products for this protein.
Showing 10 out of 122 products:
Human Polyclonal APOL1 Primary Antibody for IHC, IHC (p) - ABIN4281231
Madhavan, OToole, Konieczkowski, Ganesan, Bruggeman, Sedor: APOL1 localization in normal kidney and nondiabetic kidney disease. in Journal of the American Society of Nephrology : JASN 2011
Show all 3 Pubmed References
Human Monoclonal APOL1 Primary Antibody for ELISA, WB - ABIN968963
Vanhollebeke, Nielsen, Watanabe, Truc, Vanhamme, Nakajima, Moestrup, Pays: Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 Pubmed References
Human Polyclonal APOL1 Primary Antibody for ELISA, WB - ABIN449525
Pérez-Morga, Vanhollebeke, Paturiaux-Hanocq, Nolan, Lins, Homblé, Vanhamme, Tebabi, Pays, Poelvoorde, Jacquet, Brasseur, Pays: Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. in Science (New York, N.Y.) 2005
zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin (show NPHS1 Antibodies)
APOL1 Genetic Variations are associated with acute rejection.
These results implicate both forms of human African trypanosomiasis in the selection and persistence of otherwise detrimental APOL1 kidney disease variants.
APOL1 variant is associated with End-Stage Renal Disease.
The enhanced expression of GRP78 (show HSPA5 Antibodies) by podocytes expressing APOL1 variants would indicate endoplasmic reticulum (ER) stress.
Among patients with CKD attributed to hypertension, those with the APOL1 high-risk genotype were more likely to experience a steady decline trajectory in eGFR (show EGFR Antibodies) than those without the APOL1 high-risk genotype. These findings suggest a persistent underlying pathophysiologic process in those patients with the APOL1 high-risk genotype.
APOL1 Gene variation is associated with end-stage renal disease.
Apolipoprotein L1 and apolipoprotein A-IV (show APOA4 Antibodies) and their association with kidney function
Data suggest that APOL1 confers chloride-selective permeability to preformed phospholipid vesicles; this selectivity is strongly pH-sensitive, with maximal activity at pH 5 and little activity above pH 7; APOL1 permease activity requires calcium ions; APOL1 stably associates with phospholipid vesicles, requiring low pH and presence of negatively charged phospholipids for maximal binding.
Strict blood pressure control during chronic kidney disease associates with a lower risk of death in blacks with the high-risk CKD APOL1 genotype.
Divergent intracellular biological pathways of ancestral and variant APOL1 may explain a worsened prognosis as demonstrated in Systemic Lupus Erythematosus.
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.