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APOL1 encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Additionally we are shipping APOL1 Antibodies (137) and APOL1 Kits (34) and many more products for this protein.
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zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin (show NPHS1 Proteins)
APOL1, alpha-thalassemia, and BCL11A (show BCL11A Proteins) variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.
Among blacks with established moderate CKD, the APOL1 high-risk variants are associated with greater risk of incident proteinuria. After proteinuria onset, kidney function declines more rapidly but does not differ by APOL1 risk status.
In individuals at risk for nondiabetic kidney disease based on African ancestry, the majority of that risk can be explained by two variants in the APOL1 gene.
Considering APOL1 evolution also may help us understand how APOL1 risk variants cause kidney disease in modern humans.
APOL1 variants are associated with HIV-associated nephropathy(HIVAN), a podocyte disease,but not with HIV-immune complex disease, primarily a disease of the mesangium.
the associations of the APOL1 risk variants with microalbuminuria, incident CKD, and subsequent kidney function decline implicate a potential role in both the development and progression of CKD. Unlike the consistent association with CKD, the association of the APOL1 risk variants with cardiovascular disease is less clear.
The presence of two APOL1 renal risk variants in deceased donors shortens survival of their renal allografts. No study has examined the potential interaction of APOL1 genotype of the donors, deceased or living, and recipients.
expression of G1 or G2 APOL1 results in significantly more cell death compared with wild-type APOL1 (G0) in various human cells in culture
Genetic variant in apolipoprotein L1 is not associated with preterm birth in African American population.
This is the first report of a specific association of APOL1 with small vessel disease (SVD (show KCNJ13 Proteins)) ischemic stroke.
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.