Arachidonate 15-Lipoxygenase B Proteins (ALOX15B)

ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. Additionally we are shipping Arachidonate 15-Lipoxygenase B Antibodies (87) and Arachidonate 15-Lipoxygenase B Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX15B 247 O15296
ALOX15B 266604 Q8K4F2
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Top Arachidonate 15-Lipoxygenase B Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 to 18 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Baculovirus infected Insect Cells Human GST tag,His tag 100 μg 14 to 16 Days
Yeast Rat His tag   1 mg 60 to 71 Days
Escherichia coli (E. coli) Rat T7 tag,His tag 100 μg 15 to 18 Days

ALOX15B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus) ,

More Proteins for Arachidonate 15-Lipoxygenase B (ALOX15B) Interaction Partners

Human Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

  1. we identified a novel role for ALOX15B, and to a lesser extent ALOX15, in cholesterol homeostasis and CCL17 production in human macrophages.

  2. Results demonstrate the expression of ALOX15 and ALOX15B in failing as well as in donor hearts. ALOX15/B signaling may play an important role in heart disease, including heart failure. Isolated fibroblasts from all four chambers of the heart expressed ALOX15 as well as ALOX15B, and gene expression levels were further increased under hypoxia.

  3. Ca(2+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT domain.

  4. 15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop.

  5. these results demonstrate the strict regiospecificity of h15-LOX-2 that circumscribes its role in transcellular synthesis.

  6. This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2.

  7. The ALOX15B gene may be associated with coronary artery disease.

  8. Hpoxia-induced pulmonary vascular remodeling is associated with increased levels of 15-LO-2.

  9. ALOX15 rs11568070 polymorphisms did not discriminate for the disease or its severity.

  10. 15-LOX2 expression inhibits Myc-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia.

  11. activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin generation

  12. Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension.

  13. Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.

  14. ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4, LPS and hypoxia.

  15. Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.

  16. The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity.

  17. Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid.

  18. In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms.

  19. White tea extract induces apoptosis via PPAR gamma and 15-lipoxygenases.

  20. Results from this study suggest a 125-bp region (-157 to -33) is critical for the 15-LOX-2 promoter activity in prostate epithelial cells and cancer cells

Rabbit Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

  1. Data show that 15-LOX-2 and its product, 15(S)-HETE, are important intermediates in hypoxia-induced rabbit pulmonary artery smooth muscle cells (PASMCs) proliferation and may participate in hypoxia-induced pulmonary hypertension.

Arachidonate 15-Lipoxygenase B (ALOX15B) Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with ALOX15B

  • arachidonate 15-lipoxygenase, type B (ALOX15B)
  • arachidonate 15-lipoxygenase, type B (Alox15b)
  • arachidonate 15-lipoxygenase B (LOC100525835)
  • 15-LOX-2 protein
  • ALOX15B protein

Protein level used designations for ALOX15B

15-LOX-B , 15S-lipoxygenase , arachidonate 15-lipoxygenase 2 , arachidonate 15-lipoxygenase B , arachidonate 15-lipoxygenase type II , arachidonate 15-lipoxygenase, second type , arachidonate omega(6) lipoxygenase , arachidonate 15-lipoxygenase, type B , 15-LOX-2 , 15-lipoxygenase 2 , LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B

247 Homo sapiens
716764 Macaca mulatta
100073039 Equus caballus
286820 Bos taurus
455104 Pan troglodytes
489485 Canis lupus familiaris
266604 Rattus norvegicus
100525835 Sus scrofa
100732272 Cavia porcellus
100342479 Oryctolagus cuniculus
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