anti-Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) Antibodies

The protein encoded by DARS2 belongs to the class-II aminoacyl-tRNA synthetase family. Additionally we are shipping DARS2 Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DARS2 226539 Q8BIP0
DARS2 304919 Q3KRD0
DARS2 55157 Q6PI48
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Top anti-DARS2 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using DARS2 antibody. Immunohistochemistry of paraffin-embedded human liver injury using DARS2 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$334.77
Details
Human Rabbit Un-conjugated WB Western Blot analysis of DARS2 expression in transfected 293T cell line by DARS2 MaxPab polyclonal antibody.<br><br>Lane 1: DARS2 transfected lysate(73.60 KDa).<br>Lane 2: Non-transfected lysate.<br> DARS2 MaxPab rabbit polyclonal antibody. Western Blot analysis of DARS2 expression in human kidney. 100 μg Log in to see 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cell lines, using DARS2 antibody (ABIN5975194) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human liver injury using DARS2 antibody (ABIN5975194) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DARS2 Antibody [NBP1-83854] - Staining of human rectum shows strong cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: DARS2 Antibody [NBP1-83854] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & mitochondria. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using DARS2 antibody (ABIN5972773) at 1/1000 dilution. 100 μL Log in to see 11 to 16 Days
$412.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: DARS2 Antibody [NBP2-16102] - Immunohistochemical analysis of paraffin-embedded Colon ca, using antibody at 1:250 dilution. Western Blot: DARS2 Antibody [NBP2-16102] - Sample (30 ug of whole cell lysate) A: MCF-7 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

More Antibodies against DARS2 Interaction Partners

Mouse (Murine) Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) interaction partners

  1. Results now provide the first evidence that loss of DARS2 in neurons leads to strong mitochondrial dysfunction and progressive loss of cells.

  2. DARS2 depletion in heart and skeletal muscle leads to the severe deregulation of mitochondrial protein (show COX6B2 Antibodies) synthesis followed by a strong respiratory chain deficit in both tissues.

Human Aspartyl-tRNA Synthetase 2, Mitochondrial (DARS2) interaction partners

  1. Results show that DARS2 is strongly upregulated in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) and is associated with HCC (show FAM126A Antibodies) progression. DARS2 promotes HCC (show FAM126A Antibodies) tumorigenesis by accelerating cell cycle progression and attenuating cell apoptosis.

  2. This study identified DARS2-associated leukoencephalopathy with hypomyelination with brainstem and spinal cord involvement and leg spasticity.

  3. 60 different DARS2 mutations were identified in 78 patients with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation, 13 of which have not been reported before

  4. Cognitive impairment seems to be common among patients with leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate and DARS2 mutations

  5. A comparison of biophysical properties of human mitochondrial aspartyl-tRNA synthetase (show DARS Antibodies), HsaDRS2, with them to those of a bacterial (E. coli) homolog, EcoDRS.

  6. Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase (show DARS Antibodies) in diverse way

  7. We describe two new cases of Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate with a novel pathogenic mutation in the DARS2 gene

  8. Case demonstrates that DARS2 mutation homozygosity is not lethal, as suggested earlier, but compatible with a rather benign disease course.

  9. Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA.

  10. A novel homozygous mutation of DARS2 may cause a severe LBSL (Leukoencephalopathy with brain stem and spinal cord involvement with lactate elevation) variant.

DARS2 Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL).

Gene names and symbols associated with DARS2

  • aspartyl-tRNA synthetase 2, mitochondrial (DARS2) antibody
  • aspartyl-tRNA synthetase 2, mitochondrial (dars2) antibody
  • aspartate--tRNA ligase, mitochondrial (LOC100547893) antibody
  • aspartyl-tRNA synthetase 2 (mitochondrial) (Dars2) antibody
  • 5830468K18Rik antibody
  • ASPRS antibody
  • LBSL antibody
  • MT-ASPRS antibody
  • RGD1308286 antibody
  • RP3-383J4.2 antibody
  • si:dkey-21n10.1 antibody

Protein level used designations for DARS2

aspartyl-tRNA synthetase 2, mitochondrial , aspartyl-tRNA synthetase 2 (mitochondrial) , aspartyl-tRNA synthetase, mitochondrial , aspartyl-tRNA synthetase, mitochondrial-like , aspRS , aspartate--tRNA ligase, mitochondrial , aspartate tRNA ligase 2, mitochondrial

GENE ID SPECIES
424408 Gallus gallus
469591 Pan troglodytes
490337 Canis lupus familiaris
571144 Danio rerio
707002 Macaca mulatta
100061003 Equus caballus
100145033 Xenopus (Silurana) tropicalis
100173764 Pongo abelii
100344833 Oryctolagus cuniculus
100401842 Callithrix jacchus
100547893 Meleagris gallopavo
100602031 Nomascus leucogenys
226539 Mus musculus
304919 Rattus norvegicus
55157 Homo sapiens
538772 Bos taurus
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