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ATCAY encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Additionally we are shipping Ataxia, Cerebellar, Cayman Type Proteins (5) and many more products for this protein.
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Caytaxin's role in maintaining normal neuronal function
caytaxin binds to kinesin-1 and functions as an adaptor that mediates intracellular transport of specific cargos, one of which is the mitochondrion.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Caytaxin is a novel substrate of caspase-3, which is cleaved upstream of the CRAL-TRIO/BCH domain and which regulates MEK2 signaling
Mutations of mouse Atcay are an orthologous gene model for human Cayman ataxia.
The classical hesitant allele of Atcay is partially suppressed by CAST/Ei alleles of the nuclear export factor Nxf1.
This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type.
, Cayman ataxia
, ataxia cayman type protein