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BCL7A is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line.
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Human Polyclonal BCL7A Primary Antibody for ELISA, WB - ABIN262222
Zani, Asou, Jadayel, Heward, Shipley, Nacheva, Takasuki, Catovsky, Dyer: Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon. in Blood 1996
BCL7A, BRWD3 (show BRWD3 Antibodies), and AUTS2 demonstrate significantly higher mutation frequencies among AA cases. These genes are all involved in translocations in B-cell malignancies. Moreover, we detected a significant difference in mutation frequency of TP53 (show TP53 Antibodies) and IRF4 (show IRF4 Antibodies) with frequencies higher among CA cases. Our study provides rationale for interrogating diverse tumor cohorts to best understand tumor genomics across populations.
Data suggest that BCL7A may play an important role in cutaneous T-cell lymphoma (CTCL (show TSPYL2 Antibodies)) carcinogenesis.
Report describes BCL7A protein expression in normal lymphoid tissues and lymphomas using immunohistochemistry.
Promoter hypermethylation of BCL7a is associated with cutaneous T-cell lymphoma
deletion of genes BCL7A in early-stage mycosis fungoides.
Variants in BCL7A were strongly related to diffuse large B-cell lymphoma.
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.
B-cell CLL/lymphoma 7 protein family member A
, B-cell CLL/lymphoma-7
, B-cell CLL/lymphoma 7A