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The protein encoded by BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. Additionally we are shipping BANK1 Proteins (3) and many more products for this protein.
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Human Polyclonal BANK1 Primary Antibody for IHC, IHC (p) - ABIN4283023
Bernal-Quirós, Wu, Alarcón-Riquelme, Castillejo-López: BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling. in PLoS ONE 2013
The pre-B-cell receptor (pre-BCR (show BCR Antibodies)) signaling molecules BLNK (show BLNK Antibodies), BTK (show BTK Antibodies) and BANK1 were positively regulated by the ZFP521 (show ZNF521 Antibodies) gene, leading to enhancement of the pre-BCR (show BCR Antibodies) signaling pathway.
Following CpG stimulation of B-cells, BANK1 loss reduced p38 (show CRK Antibodies) phosphorylation (but not ERK (show EPHB2 Antibodies) or JNK (show MAPK8 Antibodies)), IL-6 (show IL6 Antibodies) secretion, & MNK1 (show MKNK1 Antibodies)/2 and eIF4E (show EIF4E Antibodies) phosphorylation. It had no effect on IL-6 (show IL6 Antibodies) mRNA stability. BANK1 does not affect release of eIF4E (show EIF4E Antibodies) by phospho-4E-BP1 (show EIF4EBP1 Antibodies).
BANK attenuates CD40 (show CD40 Antibodies)-mediated Akt (show AKT1 Antibodies) activation, thereby preventing hyperactive B cell responses.
This meta-analysis demonstrates that BANK1 rs10516487, rs3733197, and rs17266594 polymorphisms are associated with susceptibility to autoimmune diseases.
Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE.
The results of this study suggesting a mechanism for the involvement of BANK1 in the BOLD response to working memory
Single-nucleotide polymorphism in BANK1 gene is associated with sclerotic graft-versus-host disease.
The SLE susceptibility variants in the BANK1 gene may contribute to lupus by altering B cell signaling, increasing FOXO1 (show FOXO1 Antibodies) levels, and enhancing memory B cell development
The systemic lupus erythematosus variant Ala71Thr of BLK (show BLK Antibodies) severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain (show ITSN1 Antibodies) function.
Data show that single-nucleotide polymorphism rs3733197 located in the coding region of BANK1 (B-cell scaffold protein with ankyrin repeats 1) was significantly associated with serum LDL cholesterols.
Authors identified a novel balanced reciprocal translocation, t(4;14)(q24;q32.) Sequence analysis identified the partner gene as BANK1.
Our study confirms evidence for epistasis between BLK (show BLK Antibodies) and BANK1 in systemic lupus erythematosis from a Chinese population for the first time.
Our findings suggest the existence of association between BANK1 gene and autoimmune thyroid diseases
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
B-cell scaffold protein with ankyrin repeats
, B-cell scaffold protein with ankyrin repeats 1
, B-cell scaffold protein with ankyrin repeats 1 delta 2 transcript
, B-cell scaffold protein with ankyrin repeats-like
, b-cell scaffold protein with ankyrin repeats-like