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The protein encoded by BTG4 is a member of the BTG/Tob family. Additionally we are shipping B-Cell Translocation Gene 4 Kits (4) and B-Cell Translocation Gene 4 Proteins (4) and many more products for this protein.
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BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis
The intrinsic MAP kinase cascade in oocytes triggered translation of Btg4 mRNA stored in fully grown oocytes by targeting the 3' untranslated region, thereby coupling CCR4-NOT deadenylase-mediated decay of maternal mRNA with oocyte maturation and fertilization.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
IF5/BTG4 may be an aging-related gene in epithelial cells
BTG4 could contribute to chronic lymphocytic leykemia pathogenesis following inactivation by haploinsufficiency.
miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC
these data support BTG4 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers.
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle.
maternal B9.10 protein
, p30 B9.10
, B-cell translocation gene 4
, BTG family member 4
, protein BTG4
, protein PC3b