anti-BCL2-Associated Athanogene (BAG1) Antibodies

Human BCL2-Associated Athanogene (BAG1) interaction partners

1. Study in human osteosarcoma line U2OS expressing a conditional MYC-ER allele revealed that small isoform of BAG1, BAG1S, in cooperation with the HSP70 chaperone complex, selectively mediates cell survival in MYC overexpressing tumor cells and identified a set of specific pro-survival clients controlled by the HSP70/BAG1S chaperone complex.

2. Bag-1 targeted therapy might enhance the therapeutic potential of conventional anti-cancer drugs in the treatment of breast cancer.

3. BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples.

4. Targeting mTOR with rapamycin may significantly potentiate the inhibitory effect in BAG1silenced cells.

5. Here the authors show that the AF-1 domain of AR is bound by the cochaperone Bag-1L.

6. Over expression of BAG-1 may be a biomarker for cisplatin resistance in patients with primary or recurrent head and neck squamous cell carcinoma.

7. Increased BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signaling.

8. BAG-4/SODD, HSP70, and HSP90 are potential prognostic markers in node-negative breast carcinoma that merit further research.

9. interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening

10. These results suggest that Bag1 and Bag3 control the stability of the Hsc70-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 system.

11. Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells.

12. the combined effects of BAG-1 and XPD polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy.

13. Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.

14. Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1.

15. The expression of BAG-1 was upregulated in chronic non-eosinophilic rhinosinusitis.

16. BAG-1 expression was high in esophageal carcinoma tissues compared to normal esophagus. After Eca109 cells were transfected with BAG-1-siRNA, the proliferation and invasive capabilities of the cells were decreased while the apoptosis rate was enhanced.

17. BAG-1M mediates Hsp70 inhibition downstream of NF-kappaB.

18. Forced Bag-1L expression prevented Cisplatin-induced apoptosis.

19. distinct isoforms of BAG-1 had different anti-apoptotic ability in breast cancer cells treated with the 4-OH TAM.

20. BAG-1M and HspBP1 had differential impacts on the dynamic composition of steroid receptor folding complexes

Mouse (Murine) BCL2-Associated Athanogene (BAG1) interaction partners

1. These results provide evidence for an emerging role of BAG-1M in the regulation of BACE1 expression and AD pathogenesis and that targeting the BAG-1M-NF-kappaB complex may provide a mechanism for inhibiting Abeta production and plaque formation.

2. that BAG-1L over-expression protects against hypoxia/re-oxygenation injury, at least in part, by interacting with HSP70, and by accelerating the activation of PI3K/AKT pathways

3. These studies demonstrate for the first time the significance of BAG-1-mediated protein-protein interactions.

4. The BAG-1 stabilizes F508del-CFTR by direct binding, probably competing out ubiquitin to partially avoid its proteasomal degradation.

5. The membrane form of heparin binding EGF-like growth factor (ProHB-EGF) is most likely able to trigger the nuclear translocation of BAG-1 in keeping its level high.

6. Hemoxygenase 1 deficiency provoked diminished Bag-1 level upon LPS treatment

7. this study first reported the solution structure of mBAG-1-UBH and the growth factor precursor-interacting motif on the protein.

8. Bag-1 proteins function as regulators of the action of selective transcription factors.

9. during development of mouse autopods, BAG-1 expression is downregulated upon the initiation of interdigital apoptosis (BAG-1)

10. Bag1 is a regulator and marker of neuronal differentiation

11. BAG1 displays potent neuroprotective activity in vivo against stroke.

12. Since, BAG-1 is essential for cell survival, its association with tNhtt aggregates might disrupt its normal function and thereby promote polyglutamine-expanded tNhtt-induced cell death.

13. Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.

14. Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover

15. BAG-1 associates with Tau protein in an Hsc70-dependent manner.

16. BAG1 plays a key role in affective resilience and in regulating recovery from both manic-like and depression-like behavioral impairments

17. These data suggest a role for BAG-1 in mechanisms of neurogenesis in the adult mouse brain.

18. The longer p50 isoform is generated through use of an upstream, in-frame, non-AUG translation initiation codon.

19. Alternate protein isoforms arise through the use of a non-AUG (CUG) codon in addition to two downstream in-frame AUG codons.