anti-BCL2-Associated Athanogene 3 (BAG3) Antibodies

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. Additionally we are shipping BAG3 Kits (18) and BAG3 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
BAG3 9531 O95817
BAG3 29810 Q9JLV1
BAG3 293524  
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Top anti-BAG3 Antibodies at antibodies-online.com

Showing 10 out of 147 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-BAG3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HT1080 cell lysate BAG3 is supported by BioGPS gene expression data to be expressed in HT1080 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA, IHC, WB Antibody (0.1µg/ml) staining of Human Skeletal Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN1686794 (0.1 µg/mL) staining of Human Pancreas lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of BAG3 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Bag3 Picoband antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts from 293, using BAG3 (Phospho-Tyr457) Antibody. ABIN6271653 at 1/200 staining Human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of BAG3 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with Western blot analysis of BAG3 expression in K562 (A), HEK293T (B), Hela (C) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated ISt, IHC (p), WB WB Image BAG3 antibody detects BAG3 protein by Western blot analysis. A. 30 µg K562 whole cell lysate/extract 7.5 % SDS-PAGE BAG3 antibody , dilution: 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using BAG3, antibody at 1:100 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE antibody diluted at 1:1000 100 μL 3 to 4 Days
$466.18
Details

Top referenced anti-BAG3 Antibodies

  1. Human Polyclonal BAG3 Primary Antibody for ICC, IF - ABIN4282959 : Goldman, Chen, Roesly, Hill, Tome, Dvorak, Bernstein, Dvorak: Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis. in American journal of physiology. Gastrointestinal and liver physiology 2011 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal BAG3 Primary Antibody for IHC (fro), IHC (p) - ABIN537482 : Liao, Ozawa, Friess, Zimmermann, Takayama, Reed, Kleeff, Büchler: The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. in FEBS letters 2001 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal BAG3 Primary Antibody for ELISA, WB - ABIN564108 : Youn, Lee, Lim, Yoon, Lim, Jung, Yeum, Park, Youn, Lee, Lee, Ikawa, Okabe, Tsujimoto, Lee: Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. in American journal of physiology. Endocrinology and metabolism 2008 (PubMed)

  4. Human Polyclonal BAG3 Primary Antibody for ICC, IF - ABIN4282954 : Li, Chen, Cao, Li, Zhao, Zhai, Ren, Li: Bcl-2-associated athanogene 3(BAG3) is associated with tumor cell proliferation, migration, invasion and chemoresistance in colorectal cancer. in BMC cancer 2019 (PubMed)

  5. Human Polyclonal BAG3 Primary Antibody for IHC, IHC (p) - ABIN4282955 : Nymoen, Hetland Falkenthal, Holth, Ow, Ivshina, Tropé, Kuznetsov, Staff, Davidson: Expression and clinical role of chemoresponse-associated genes in ovarian serous carcinoma. in Gynecologic oncology 2015 (PubMed)

More Antibodies against BAG3 Interaction Partners

Zebrafish BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models.

  2. This study therefore identifies both BAG3 reduction and autophagy promotion as potential therapies for FLNC(W2710X) myofibrillar myopathy, and identifies protein insufficiency due to sequestration, compounded by impaired autophagy, as the cause.

  3. findings showed that the P209L mutation causes BAG3 to aggregate; proposed that the gradual loss of available BAG3(wt) and BAG3(P209L) proteins results in insufficiency leading to myofibrillar disintegration

Human BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. BAG3 mutation causes adult onset Charcot-Marie-Tooth disease, type 2.

  2. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway.

  3. BAG3 silencing-mediated correction of F508del-CFTR restores the autophagy pathway, which is defective in F508del-CFTR-expressing cells, likely because of the maladaptive stress response in cystic fibrosis pathophysiology.

  4. this is the first Korean patient with BAG3 mutation. We described a BAG3 mutation patient with atypical phenotype of CMT and myopathy, and those are expected to broaden the clinical spectrum of the disease and help to diagnose it.

  5. High BAG3 expression is associated with Cervical Cancer Cell Proliferation.

  6. This case indicates that rigid spine syndrome and sensory-motor axonal neuropathy are key clinical features of BAG3 mutations that should be considered even without cardiac involvement.

  7. BAG3 interaction with HSPB8 promotes spatial sequestration of ubiquitinated proteins. BAG3 mutation P209L in the HSPB8-binding motif deregulated association between BAG3 and SQSTM1 and the KEAP1-Nrf2 signaling axis.

  8. BAG3 in particular, and maybe nucleotide exchange factors in general, are a potential Achilles heel of the Hsp70 machinery, where minor malfunctioning results in the entrapment of the whole chaperone complex with disastrous consequences for protein homeostasis.

  9. BAG3 overexpression in colorectal cancer can promote tumor proliferation, migration and invasion.

  10. There was no association of SNPs in ADRB1, GRK5 and BAG3 genes with Takotsubo cardiomyopathy.

  11. These findings provide a molecular basis for understanding of BAG3dependent cell proliferation and survival from the aspect of alteration of gene expression.

  12. BAG3 can modulate the levels, localization or activity of its partner proteins, thereby regulating major cell pathways and functions, including apoptosis, autophagy, mechanotransduction, cytoskeleton organisation, motility.

  13. Genetic and pharmacological interference with BAG3 is capable to resensitize TNBC cells to treatment.

  14. The HSF1-BAG3-Mcl-1 signal axis is critical for protection of mutant KRAS colon cancer cells from AUY922-induced apoptosis.

  15. The Hsp70-Bag3 complex therefore functions as an important signaling node that senses proteotoxicity and triggers multiple pathways that control cell physiology, including activation of protein aggregation.

  16. study revealed oncogenic roles of BAG3 in chondrosarcoma and provided mechanisms that the BAG3-modulated the expression of RUNX2 through upregulation of beta-catenin.

  17. BAG3 interacted with CXCR4 mRNA and promoted its expression via its coding and 3'-untranslational regions.

  18. HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3.

  19. Silencing of HSPB8 markedly decreased the mitotic levels of BAG3 in HeLa cells, supporting its crucial role in BAG3 mitotic functions. The results support a role for the HSPB8-BAG3 chaperone complex in quality control of actin-based structure dynamics that are put under high tension, notably during cell cytokinesis.

  20. Our findings suggest that high levels of BIS expression might confer stem-cell-like properties on cancer cells through STAT3 stabilization

Mouse (Murine) BCL2-Associated Athanogene 3 (BAG3) interaction partners

  1. expression of the co-chaperone BAG3 and other chaperone-assisted selective autophagy factors was analyzed in the cellular, zebrafish and ky/ky mouse models.

  2. It is a cochaperone that mediates autophagy.

  3. Thus, BAG3 is critical for the protein turnover of small HSPs via activation of autophagy in the heart.

  4. BAG3 plays a relevant role in regulating SNCA clearance via macroautophagy, and the heat shock protein 70-BAG3-sequestosome 1 complex may be involved in this process.

  5. BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.

  6. BAG3 expression is required for neuronal differentiation and migration.

  7. interaction between BAG3 and HSP70 is essential for BAG3 to stabilize small heat shock proteins and maintain cardiomyocyte protein homeostasis

  8. The spatial regulation of mTORC1 exerted by BAG3 apparently provides the basis for a simultaneous induction of autophagy and protein synthesis to maintain the proteome under mechanical strain.

  9. Genetic variation in BAG3 plays an important role in the prevention of ischemic tissue necrosis.

  10. The aim of this study was to investigate the possible hemodynamic effects of BAG3 performing both in vitro and in vivo experiments.

  11. Our findings that BAG3 is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2+) channel provide novel insight into the role of BAG3 in cardiomyopathies and increased arrhythmia risks in heart failure.

  12. molecular association of MyHC and BIS is necessary for MyHC stabilization in skeletal muscle.

  13. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

  14. Bis is upregulated in astrocytes after hypoxia-ischemia; hypoxia-ischemia induces progressive cell death in the hippocampi of bis-positive mice, while hippocampal neurons are less vulnerable to hypoxia-ischemia in mice that lack Bis.

  15. Deletion of the bis gene results in a marked increase in the production of corticosterone that is associated with thymic atrophy.

  16. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.

  17. Results indicate that Bis functions to mediate cellular regulation of the stem cell niche on the vascular compartment.

  18. BAG3 alters the interaction between HSP70 and IKKgamma, increasing availability of IKKgamma and protecting it from proteasome-dependent degradation; this, in turn, results in increased NF-kappaB activity and survival

  19. BAG3 is not required for muscle development, this co-chaperone appears to be critically important for maintenance of mature skeletal muscle.

  20. The absence of Bis has considerable influences on postnatal growth and survival, possibly due to a nutritional impairment.

BAG3 Antigen Profile

Protein Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.

Gene names and symbols associated with BAG3

  • BCL2 associated athanogene 3 L homeolog (bag3.L) antibody
  • BCL2-associated athanogene 3 (bag3) antibody
  • BCL2 associated athanogene 3 (BAG3) antibody
  • BCL2 associated athanogene 3 (bag3) antibody
  • BCL-2-associated athanogene 3 (BAG3) antibody
  • BCL2-associated athanogene 3 (Bag3) antibody
  • Bcl2-associated athanogene 3 (Bag3) antibody
  • AA407278 antibody
  • ATBAG3 antibody
  • BAG-3 antibody
  • BAG3 antibody
  • bag3-A antibody
  • BCL-2-associated athanogene 3 antibody
  • Bis antibody
  • CAIR-1 antibody
  • MFM6 antibody
  • mg638 antibody
  • MGC53113 antibody
  • T28J14.160 antibody
  • T28J14_160 antibody
  • zgc:100859 antibody

Protein level used designations for BAG3

BCL2-associated athanogene 3 , BAG family molecular chaperone regulator 3 , BAG family molecular chaperone regulator 3-like , BCL2-binding athanogene 3 , bcl-2-binding protein Bis , docking protein CAIR-1 , BAG-3 , Bcl-2-binding protein Bis , Bcl-2-interacting death suppressor , bcl-2-associated athanogene 3

GENE ID SPECIES
379174 Xenopus laevis
445139 Danio rerio
450778 Pan troglodytes
714420 Macaca mulatta
100145358 Xenopus (Silurana) tropicalis
100228262 Taeniopygia guttata
100481230 Ailuropoda melanoleuca
830613 Arabidopsis thaliana
9531 Homo sapiens
29810 Mus musculus
293524 Rattus norvegicus
486916 Canis lupus familiaris
782633 Bos taurus
423931 Gallus gallus
100156989 Sus scrofa
100358030 Oryctolagus cuniculus
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