BR serine/threonine Kinase 2 Proteins (BRSK2)

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Additionally we are shipping BR serine/threonine Kinase 2 Antibodies (86) and BR serine/threonine Kinase 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRSK2 9024 Q8IWQ3
BRSK2 75770 Q69Z98
BRSK2 293631  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top BR serine/threonine Kinase 2 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$4,148.83
Details
Insect Cells Human GST tag 5 μg 11 to 12 Days
$516.00
Details
Insect Cells Human GST tag   10 μg 3 to 4 Days
$310.00
Details

BRSK2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for BR serine/threonine Kinase 2 (BRSK2) Interaction Partners

Human BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. the intrinsic molecular merit that BRSK2 provides is a survival advantage to PDAC cells and strengthens the invasiveness of these neoplastic cells in energy-deprived environments.

  2. SAD-A and AMPK kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  3. BRSK2 interacted with VCP/p97 via three of the four functional domains of VCP/p97. Immunofluorescence demonstrated that BRSK2 and VCP/p97 were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta.

  4. Anaphase-promoting complex/cyclosome-Cdh1, rather than Cdc20, promotes the degradation of BRSK2 in vivo.

  5. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  6. these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.

  7. these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1.

  8. BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.

  9. BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.

  10. we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.

  11. protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.

  12. level of SAD within neurons is modulated by TORC1

  13. STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2

Mouse (Murine) BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. SAD-A is activated by the incretin hormone GLP-1 in pancreatic beta-cell. SAD-A promotes the phosphorylation of Bad S155.

  2. Glucose and incretin stimulate insulin secretion through the phosphorylation of GDIalpha at Ser174 by SAD-A, which leads to the activation of Rho GTPases, culminating in insulin exocytosis.

  3. Taken together, these data suggest a model for synergistic autoinhibition and membrane activation of SAD kinases.

  4. SAD-A and AMPK kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  5. SAD-A and SAD-B kinases have multiple, sequential roles in axonal differentiation

  6. SAD-A kinase controls islet beta-cell size and function as a mediator of mTORC1 signaling.

  7. SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.

  8. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  9. a critical role of SAD-A in the activation of PAK1 during the onset of insulin exocytosis.

  10. The regulation of Wee1 by SadA and SadB kinases is essential for the differentiation of polarized neurons.

  11. results show that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

  12. Once activated, LKB1 phosphorylates and thereby activates SAD-A and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex.

BR serine/threonine Kinase 2 (BRSK2) Protein Profile

Protein Summary

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.

Gene names and symbols associated with BRSK2

  • BR serine/threonine kinase 2 (BRSK2)
  • BR serine/threonine kinase 2 (Brsk2)
  • 4833424K13Rik protein
  • BRSK2 protein
  • C11orf7 protein
  • PEN11B protein
  • SAD-A protein
  • SAD1 protein
  • SADA protein
  • STK29 protein

Protein level used designations for BRSK2

BR serine/threonine-protein kinase 2 , brain-selective kinase 2 , brain-specific serine/threonine-protein kinase 2 , protein kinase SAD1B , serine/threonine-protein kinase 29 , serine/threonine-protein kinase BRSK2 , serine/threonine-protein kinase SAD-A , BR serine/threonine kinase 2 , BR serine/threonine-protein kinase 2-like , brain serine/threonine kinase 2

GENE ID SPECIES
9024 Homo sapiens
423098 Gallus gallus
535868 Bos taurus
746226 Pan troglodytes
100395256 Callithrix jacchus
100429659 Macaca mulatta
100443903 Pongo abelii
75770 Mus musculus
293631 Rattus norvegicus
483658 Canis lupus familiaris
Selected quality suppliers for BR serine/threonine Kinase 2 Proteins (BRSK2)
Did you look for something else?