BCCIP Proteins

Protein Summary

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BCCIP

• BRCA2 and CDKN1A interacting protein (BCCIP) antibody
• BRCA2 and CDKN1A interacting protein (bccip) antibody
• BRCA2 and CDKN1A interacting protein L homeolog (bccip.L) antibody
• BRCA2 and CDKN1A interacting protein (Bccip) antibody

• 1110013J05Rik antibody
• BCCIP antibody
• DKFZp459K2416 antibody
• MGC82792 antibody
• MGC89311 antibody
• Show all synonym aliases
• mp:zf637-1-000774 antibody
• TOK-1 antibody
• TOK1 antibody
• zgc:110272 antibody

Protein level used designations for BCCIP

BRCA2 and CDKN1A interacting protein , protein BCCIP homolog , BRCA2 and CDKN1A-interacting protein , bccip-like , BCCIPalpha , BCCIPbeta , BRCA2 and Cip1/p21 interacting protein , TOK-1alpha , TOK-1beta , cdk inhibitor p21 binding protein , p21- and CDK-associated protein 1 , protein TOK-1