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BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. Additionally we are shipping BHLHE22 Kits (13) and BHLHE22 Proteins (5) and many more products for this protein.
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Cow (Bovine) Polyclonal BHLHE22 Primary Antibody for WB - ABIN2779635
McLellan, Langlands, Kealey: Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening. in Mechanisms of development 2003
These observations suggest a different regulatory mechanism on bhlhe22 expression by smarca4 and irx7
atoh1.2 and beta3.1 are transcribed in distinct precursors.
Segregates with Duane syndrome. Brain-specific expression with the highest abundance in the cerebellum.
Bhlhb5 is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus during development. Mice lacking Bhlhb5 had a diminished number of neurons. A Bhlhb5::flpo allele also genetically labels numerous other regions of the nervous system processing sensory input, including the dorsal horn, the retina, and the nucleus of the lateral olfactory tract.
hypothesis that neuropathic itch in BHLHB5-deficient animals can be treated by restoring inhibitory controls through spinal cord transplantation and integration of precursors of inhibitory interneurons derived from embryonic medial ganglionic eminence
Bhlhb5 is broadly expressed throughout retinogenesis, and is required for the subtype development of amacrine and bipolar cells.
These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11.
Atonal-related transcription factor Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritis, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch.
BETA3 function is linked to the establishment rather than the initiation of neuronal fates
Mouse Bhlhb5 can strongly repress a human PAX6 promoter. A single exon encodes a 355-amino-acid bHLH protein.
Localization of Bhlhb5 mRNA expression in the central nervous system and sensory organs of the mouse embryo.
The results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes.
These results show Bhlhb5's function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization.
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002
basic helix-loop-helix domain containing, class B, 5
, basic helix-loop-helix family, member e22
, class E basic helix-loop-helix protein 22
, class B basic helix-loop-helix protein 5
, trinucleotide repeat containing 20
, trinucleotide repeat-containing gene 20 protein
, basic helix-loop-helix (bHLH) gene, class B, beta3
, basic helix-loop-helix domain containing, class B5