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BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. Additionally we are shipping BLOC1S1 Kits (13) and BLOC1S1 Proteins (11) and many more products for this protein.
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The mitochondrial acetylation status controlled by Sirt3 (show SIRT3 Antibodies) and its proposed opponent GCN5L1 is an important regulator of the metabolic adaptation of mitochondrial translation.
Using cancer cell lines, the study shows that BLOC1S1 mRNA is specifically cleaved by IRE1 (show ERN1 Antibodies) at guanine 444, but only under conditions of IRE1 (show ERN1 Antibodies) hyperactivation.
The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton.
BLOS1 interacts with KXD1.
GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria.
Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility.
Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis.
Experimental investigation of five specific genes, AP3B1 (show AP3B1 Antibodies), ATP6AP1 (show ATP6AP1 Antibodies), BLOC1S1, LAMP2 (show LAMP2 Antibodies), and RAB11A (show RAB11A Antibodies), has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.
Biogenesis of Lysosome-related Organelles co (show SNAPIN Antibodies)mplex-1 (BLOC-1) subunit 1 (BLOS1).
Data show that the mitochondrial enriched GCN5 (show KAT2A Antibodies)-like 1 protein (GCN5L1) controls hepatic glucose production by regulating FoxO1 (show FOXO1 Antibodies) protein levels.
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
TDH, responsible for mitochondrial production of acetyl-CoA (show LPCAT1 Antibodies) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15 (show FBXO15 Antibodies), an F-box protein (show FBXO30 Antibodies) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
BLOS1 interacts with sorting nexin 2 (show SNX2 Antibodies) and the ESCRT-I (show VPS28 Antibodies) component TSG101 (show TSG101 Antibodies) to mediate the sorting of EGFR (show EGFR Antibodies) into endosomal compartments
Here we show that genetic deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB (show TFEB Antibodies)), which acts as a master regulator of autophagy.
Mutations in the human genes encoding Snapin (show SNAPIN Antibodies) and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models
Defects in all the 5 known components of BLOC-1 (show PLDN Antibodies), including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 (show PLDN Antibodies) plays a key role in organelle biogenesis.
These results indicate that the BLOC-1 (show PLDN Antibodies) and AP-3 (show AP3B1 Antibodies) protein complexes affect the targeting of SNARE (show VTI1B Antibodies) and non-SNARE (show VTI1B Antibodies) AP-3 (show AP3B1 Antibodies) cargoes and suggest a function of the BLOC-1 (show PLDN Antibodies) complex in membrane protein sorting.
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004
BLOC subunit 1
, BLOC-1 subunit 1
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1
, GCN5 general control of amino-acid synthesis 5-like 1
, GCN5-like protein 1
, MTA1-interacting coactivator
, biogenesis of lysosome-related organelles complex 1 subunit 1
, biogenesis of lysosome-related organelles complex-1, subunit 1
, GCN5 general control of amino acid synthesis-like 1
, general control of amino acid synthesis, yeast homolog-like 1
, general control of amino acid synthesis-like 1