Breast Cancer Anti-Estrogen Resistance 3 Proteins (BCAR3)

Human Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

1. BCAR3 is an essential interactor and mediator of HEF1 (show NEDD9 Proteins)-induced migration.

2. BCAR3 acts as a putative suppressor of breast cancer progression by inhibiting the prometastatic TGFbeta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathway in invasive breast tumors.

3. BCAR1 (show BCAR1 Proteins) and BCAR3 scaffolding proteins have roles in cell signaling and antiestrogen resistance

4. Taken together, these results demonstrated that BCAR3 plays an important role in the signaling pathways of insulin (show INS Proteins) leading to cell cycle progression and cytoskeleton reorganization, but not GLUT4 (show SLC2A4 Proteins) translocation.

5. BCAR3 promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells.

6. BCAR3 expression may regulate Src (show SRC Proteins) signaling in a BCAR3-p130(cas (show BCAR1 Proteins)) complex-dependent fashion by altering the ability of the Src (show SRC Proteins) SH3 domain (show ITSN1 Proteins) to bind the p130(cas (show BCAR1 Proteins)) SBD (show TRAPPC4 Proteins)

7. BCAR3-p130Cas complex formation is not required for BCAR3-mediated anti-estrogen resistance, Rac ac (show BCAR1 Proteins)tivation or discohesion of epithelial breast cancer cells

8. the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes

9. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner

10. BCAR3 and NSP1 (show SH2D3A Proteins) are more highly expressed than SH2D3C (SHEP1 (show SH2D3C Proteins)) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.

Mouse (Murine) Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

1. The first spontaneous mutation in the Bcar3 gene associated with lens extrusion cataracts.

2. data presented here suggest that Bcar3 could play a role in testis development

3. many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas (show BCAR1 Proteins) association

4. p130Cas (show BCAR1 Proteins)- and HEF1 (show NEDD9 Proteins)-associated AND-34 may regulate B cell adhesion and motility through a Cdc42 (show CDC42 Proteins)-mediated signaling pathway.

5. study presents a pluridisciplinary approach, including small-angle X-ray scattering, that provides first insights into the structure of the complex formed between BCAR3 and human enhancer of filamentation 1 (HEF1 (show NEDD9 Proteins))

Xenopus laevis Breast Cancer Anti-Estrogen Resistance 3 (BCAR3) interaction partners

1. bcar3 gene is expressed downstream of Gata2 (show GATA2 Proteins) during gastrulation, and is co-expressed with gata2 (show GATA2 Proteins) but is more broadly expressed during later development; its binding partner, bcar1 (show BCAR1 Proteins) shows overlapping expression patterns