Breast Cancer Anti-Estrogen Resistance 3 Proteins (BCAR3)

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

• breast cancer anti-estrogen resistance 3 (BCAR3)
• breast cancer anti-estrogen resistance 3 (Bcar3)
• breast cancer anti-estrogen resistance 3 (bcar3)
• breast cancer anti-estrogen resistance 3 L homeolog (bcar3.L)

• AI131758 protein
• AND-34 protein
• BCAR3 protein
• NSP2 protein
• SH2D3B protein

SH2 domain-containing protein 3B , breast cancer anti-estrogen resistance protein 3 , breast cancer antiestrogen resistance 3 protein , dJ1033H22.2 (breast cancer anti-estrogen resistance 3) , novel SH2-containing protein 2 , p130Cas-binding protein AND-34 , breast cancer anti-estrogen resistance 3 , breast cancer antiestrogen resistance 3 , breast cancer anti-estrogen resistance protein 3-like