Bromodomain Containing 7 Proteins (BRD7)

BRD7 encodes a protein which is a member of the bromodomain-containing protein family. Additionally we are shipping BRD7 Antibodies (67) and BRD7 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
BRD7 29117 Q9NPI1
BRD7 26992 O88665
Rat BRD7 BRD7 361374  
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Top BRD7 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 2 to 3 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human GST tag Recombinant BRD7 (129-236), GST-tag activity using AlphaLISA. BRD7 (129-236), GST-tag was used in an AlphaLISA assay to determine enzyme linearity. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRD7 (129-236), GST-tag protein gel. BRD7 (129-236), GST-tag protein was run on an SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant BRD7 (129-236) activity using AlphaScreen. BRD7 (129-236) titration was assessed using an AlphaScreen® assay. Titration curves were generated to show signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant BRD7 (129-236) protein gel. BRD7 (129-236) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days

BRD7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Bromodomain Containing 7 (BRD7) Interaction Partners

Human Bromodomain Containing 7 (BRD7) interaction partners

  1. the transcriptional signature of low BRD7 expressing cells is associated with increased angiogenesis.

  2. our data indicated that BRD7 may serve as a tumor suppressor in hepatocellular carcinoma

  3. Results demonstrate a novel function of BRD7 in TGF-beta signaling. BRD7 interacts with the Smad tumor suppressor complex, and enhances both DNA-binding ability and transcriptional activity of Smads. BRD7 functions in growth inhibition and tumor suppression partly as a transcriptional co-activator of Smads.

  4. Overexpression of BRD7 inhibited cyclin D and myc expression. Our findings are consistent with a tumor suppressor role for BRD7 in lung adenocarcinoma tumorigenesis.

  5. the expression of miR-141 in BRD7-overexpressing NPC cells could partially reverse the tumor suppressive effect of BRD7 on cell proliferation and tumor growth in vitro and in vivo.

  6. constructed a regulating network of BRD7 downstream genes, and this network suggests multiple feedback regulations of the pathways. Furthermore, we validated BIRC2, BIRC3, TXN2, and NOTCH1 genes as direct, functional BRD7 targets

  7. Propose that the balance between BRD7 function and Ras/Raf/MEK/ERK activity is important for determining the outcomes of HCV infection and HCC development.

  8. Ectopic expression of BRD7 could significantly inhibit miR-300-promoted proliferation, invasion and epithelial-mesenchymal transition in osteosarcoma.

  9. BRD7 promoter hypermethylation is an indicator of well differentiated oral squamous cell carcinomas.

  10. Data indicate that bromodomain-containing protein 7 (BRD7) was a direct target of microRNA-410 (miR-410).

  11. lower BRD7 expression is an indicator for poor prognosis in patients with osteosarcoma.

  12. These results suggested that BRD7 acts as a tumor suppressor in epithelial ovarian cancers

  13. Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4.

  14. BRD7-mediated translocation of a subfraction (but not all) of the p85 protein to the nucleus could enhance PI3K signaling.

  15. No evidence for breast cancer susceptibility is associated with variants of BRD7.

  16. Data show a substantial proportion of germ-line mutations in triple-negative breast cancer (TNBC), with a preponderance of BRCA1 mutations over mutations in BRCA2 or PALB2, but no evidence to implicate BRD7 mutations in the etiology of TNBC.

  17. The region from aa219 to aa450 is primarily defined as an atypical nuclear export signal in BRD7.

  18. Data indicate that BRD7 may be related to the occurrence, development, and metastasis of lung cancers.

  19. miR-200c inhibits the expression of BRD7. MiR-200c regulated the translocation of beta-catenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc.

  20. All-trans retinoic acid enhances brd7 gene expression as HL-60 cells differentiate.

Mouse (Murine) Bromodomain Containing 7 (BRD7) interaction partners

  1. A novel basis for understanding the molecular dynamics of glucose metabolism and the unique function of BRD7 in the regulation of glucose homeostasis.

  2. these findings suggest that BRD7 has an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-small ka, CyrillicB signaling pathway, which provides evidence to aid in understanding the therapeutic effects of BRD7 on inflammatory diseases

  3. Furthermore, Brd7 inhibition alters the phenotype of macrophages and promotes plaque instability, at least partly via STAT6 signaling. Our data define a previously undescribed role of Brd7 in the development of atherosclerosis.

  4. Homozygous BRD7 knockout (KO) mice showed retardation in development.

  5. Homozygous knockout of BRD7 (BRD7(-/-)) resulted in complete male infertility and spermatogenesis defects, including deformed acrosomal formation, degenerative elongating spermatids and irregular head morphology in postmeiotic germ cells in the seminiferous epithelium, which led to the complete arrest of spermatogenesis at step 13.

  6. Results link BRD7 to medial prefrontal cortex synaptic plasticity regulation; knockout leads to impaired cognitive behavior accompanied by reduced synaptic related proteins expression and dendritic spines or branching in the medial prefrontal cortex

  7. BRD7 interacts with the regulatory subunits of phosphatidylinositol 3-kinase (PI3K) and increases the nuclear translocation of both p85alpha and p85beta and the spliced form of XBP1 (XBP1s).

  8. TRIM24 regulates AR-mediated transcription in collaboration with TIP60 and BRD7.

  9. BRD7 is a novel PBAF-specific SWI/SNF subunit that is required for target gene activation and repression in embryonic stem cells

BRD7 Protein Profile

Protein Summary

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with BRD7

  • bromodomain containing 7 L homeolog (brd7.L)
  • bromodomain containing 7 (brd7)
  • bromodomain containing 7 (BRD7)
  • bromodomain containing 7 (Brd7)
  • BP75 protein
  • BRD7 protein
  • CELTIX1 protein
  • MGC79478 protein
  • NAG4 protein
  • Ptpn13ip protein
  • wu:fc95f02 protein
  • zgc:66347 protein

Protein level used designations for BRD7

bromodomain containing 7 , nuclear transcriptor-like protein , bromodomain-containing protein 7-like , bromodomain-containing protein 7 , 75 kDa bromodomain protein , protein CELTIX-1 , bromodomain protein 75 kDa , bromodomain-containing 7 , protein tyrosine phosphatase, non-receptor type 13 interacting protein

398590 Xenopus laevis
406675 Danio rerio
493370 Xenopus (Silurana) tropicalis
694850 Macaca mulatta
100404973 Callithrix jacchus
411112 Apis mellifera
29117 Homo sapiens
26992 Mus musculus
415730 Gallus gallus
478130 Canis lupus familiaris
526153 Bos taurus
361374 Rattus norvegicus
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