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Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity).. Additionally we are shipping CDKN2A Interacting Protein Antibodies (65) and CDKN2A Interacting Protein Kits (6) and many more products for this protein.
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a comprehensive current understanding into the molecular mechanisms of CARF functions in regulation of DNA damage response, cell cycle checkpoints, cell survival and death signaling pathways.
report that CARF (Collaborator of ARF) is a new target of miR (show MLXIP Proteins)-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB (show RB1 Proteins), HDM2 and p21(WAF1 (show CDKN1A Proteins))
Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin (show CTNNB1 Proteins)/TCF (show HNF4A Proteins) signaling.
CARF promotes carcinogenesis in p53 (show TP53 Proteins)-deficient cells by repressing p21WAF1 and promoting cell cycle progression.
The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 (show XRN2 Proteins) between the nucleoplasm and nucleolus.
CARF regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 (show USP20 Proteins) and OR7C2 (show OR7C2 Proteins) in a Korean population.
CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM (show ATM Proteins) and gammaH2AX (show H2AFX Proteins), leading to induction of mitotic arrest and eventual apoptosis.
CARF may act as a novel key regulator of the p53 (show TP53 Proteins) pathway at multiple checkpoints
cooperates with human p14ARF in activating p53 (show TP53 Proteins)
Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity).
, collaborates/cooperates with ARF (alternate reading frame) protein
, collaborator of ARF
, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
, calcium-response factor
, calcium-responsive transcription factor
, testis development protein NYD-SP24
, CDKN2A interacting protein
, protein CDKN2AIP homolog A