Calcium and Integrin-Binding Protein 1 Proteins (CIB1)

CIB1 encodes a member of the EF-hand domain-containing calcium-binding superfamily. Additionally we are shipping CIB1 Antibodies (119) and CIB1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CIB1 10519 Q99828
CIB1 23991 Q9Z0F4
CIB1 81823 Q9R010
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Top CIB1 Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human CIB1 Protein. 100 μg Log in to see 11 to 18 Days
$525.90
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$400.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,454.83
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,454.83
Details

CIB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Calcium and Integrin-Binding Protein 1 (CIB1) Interaction Partners

Human Calcium and Integrin-Binding Protein 1 (CIB1) interaction partners

  1. In patients with chronic stable ischemic heart failure, the diagnostic value of urine CIB1 outperforms that of serum pro-BNP

  2. this study identifies CIB1 and CIB2 (show CIB2 Proteins) as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry

  3. In summary, as a multifunctional protein, CIB1 serving not only as a Ca2 (show CA2 Proteins)+ modulating protein, most surprisingly, but also as an important potential tumor promoting factor. [review]

  4. Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.

  5. we found that ectopic expression of oncogenic KRas and HRas (show HRAS Proteins) in cells resulted in elevated CIB1 expression. We previously described the Ca(2 (show CA2 Proteins)+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1 (show SPHK1 Proteins)), a location where SK1 is known to elicit oncogenic signalling.

  6. a large subset of TNBCs depend on CIB1 for cell survival and tumor growth, independent of CIB1 expression levels.

  7. mRNA and protein expression levels of CIB1 were decreased in the oligoasthenozoospermia patients.CIB1 may be involved in the pathogenesis of oligoasthenozoospermia by the CDK1 (show CDK1 Proteins) signaling pathway.

  8. High serum CIB1 levels are associated with pancreatic cancer.s

  9. KIP binding to TRF2 (show TERF2 Proteins) enhances the telomere-binding activity of TRF2 (show TERF2 Proteins), suggesting that KIP acts as a positive regulator of TRF2 (show TERF2 Proteins) function.

  10. these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 (show EPHA2 Proteins) mediated signaling involved in its entry

Mouse (Murine) Calcium and Integrin-Binding Protein 1 (CIB1) interaction partners

  1. results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.

  2. CIB1 is involved in regulating endomitosis, perhaps through its interaction with Polo-like kinase 3 (show PLK3 Proteins)

  3. Data demonstrate that CIB1 is not required for AID to mediate antibody gene diversification processes. It remains possible that CIB1 has an alternative, a redundant or a subtle non-limiting regulatory role in AID biology.

  4. CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.

  5. CIB1 is a key regulator of thrombosis, by affecting platelet spreading, but not platelet filopodia formation.

  6. CIB co-immunoprecipitated with Snk (show ATP1A4 Proteins) and inhibited the kinase activity of Snk (show ATP1A4 Proteins), suggesting that CIB is a negative regulator for Snk (show ATP1A4 Proteins) kinase activity.

  7. MEFs derived from Cib1(-/-) mice exhibit a much slower growth rate compared to Cib1(+/+) MEFs, suggesting that CIB1 regulates the cell cycle, differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

  8. loss of CIB1 in endothelial cells decreases p21-activated kinase 1 (show PAK1 Proteins) activation, downstream extracellular signal-regulated kinase 1/2 (show MAPK3 Proteins) activation, and matrix metalloproteinase 2 (show MMP2 Proteins) expression, all of which are known to contribute to angiogenesis.

CIB1 Protein Profile

Protein Summary

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CIB1

  • calcium and integrin binding 1 (calmyrin) (cib1)
  • calcium and integrin-binding protein 1 (CpipJ_CPIJ003501)
  • calcium and integrin binding 1 (CIB1)
  • calcium and integrin binding 1 (cib1)
  • Calcium and integrin-binding protein 1 (kip1)
  • calcium and integrin binding 1 (calmyrin) (Cib1)
  • calcium and integrin binding 1 (Cib1)
  • Cib protein
  • Cibkip protein
  • CIBP protein
  • Kip protein
  • KIP1 protein
  • Prkdcip protein
  • Sip2-28 protein
  • zgc:112015 protein

Protein level used designations for CIB1

calcium and integrin-binding protein 1 , calcium and integrin binding protein 1 , Calcium and integrin-binding protein 1 , DNA-PK interaction protein , DNA-PKcs-interacting protein , DNA-dependent protein kinase interacting protein , SNK-interacting protein 2-28 , CIB , calcium and integrin binding, protein kinase interacting protein , calmyrin , kinase-interacting protein , protein kinase, DNA activated, catalytic polypeptide interacting protein , KIP , calcium- and integrin-binding protein

GENE ID SPECIES
550376 Danio rerio
6034872 Culex quinquefasciatus
100141300 Ovis aries
100286603 Salmo salar
100301714 Oncorhynchus mykiss
10519 Homo sapiens
23991 Mus musculus
81823 Rattus norvegicus
479044 Canis lupus familiaris
100157484 Sus scrofa
510141 Bos taurus
100726412 Cavia porcellus
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