Calcyphosine 2 Proteins (CAPS2)

Mouse (Murine) Calcyphosine 2 (CAPS2) interaction partners

1. Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release

2. that CAPS2 deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons

3. These results suggest that Caps2 KO mice have altered endocrine responses to CORT administration, while maintaining CORT-induced anxiety/depressive-like behavior.

4. Naturally occurring splice variants of CAPS2 in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 primes vesicles independently of its MUN domain.

5. possible association of the dense-core vesicle secretion-related gene,CAPS2 with autism specturum disorder. (review)

6. CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis

7. CAPS2 promotes activity-dependent brain-derived neurotrophic factor secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.

8. CAPS2 KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders

9. These results demonstrate that the CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 is probably involved in BDNF secretion in many brain areas.

10. CAPS2-mediated neurotrophin release is indispensable for normal cerebellar development and functions, including neuronal differentiation and survival, morphogenesis, synaptic function, and motor learning/control.

11. In mouse, there are six splicing variants of CAPS2 (CAPS2a-f), and that these are subdivided into two groups: a long form containing the C-terminal Munc13-1-homologous domain (MHD) and a short form lacking the C-terminal MHD.

12. Data demonstrate that CAPS-1 and -2 generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2+) triggered release of transmitters.

13. Although CAPS2 proteins are not required for Ca(2+)-dependent exocytosis to proceed, they exert a modulatory effect on insulin granule priming, exocytosis, and stability.

14. The CAPS2-deficient mice show reduced secretion of BDNF and NT-3. And the cerebella of these mice exhibit developmental deficits, such as delayed development.

15. Discusses cloning of the human homolog of mouse Caps2 (GeneID: 353025).