Calcyphosine 2 Proteins (CAPS2)

Human Calcyphosine 2 (CAPS2) interaction partners

1. These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 (show CADPS2 Proteins) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

2. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2 (show CADPS2 Proteins)/D2DR (show DRD2 Proteins) interaction.

3. We speculate that haploinsufficiency of CADPS2 (show CADPS2 Proteins) contributes to ASDs.

4. identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Proteins) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (show CAPS Proteins)

5. Results from Cadps2 (show CADPS2 Proteins)-deficient mice and human data suggest that a disturbance in CADPS2 (show CADPS2 Proteins)-mediated neurotrophin (show BDNF Proteins) release contributes to autistic-like cellular and behavioral phenotypes.

6. CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2

Mouse (Murine) Calcyphosine 2 (CAPS2) interaction partners

1. that CAPS2 (show CADPS2 Proteins) deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons

2. These results suggest that Caps2 (show CADPS2 Proteins) KO mice have altered endocrine responses to CORT (show CORT Proteins) administration, while maintaining CORT (show CORT Proteins)-induced anxiety/depressive-like behavior.

3. Naturally occurring splice variants of CAPS2 (show CADPS2 Proteins) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (show CADPS2 Proteins) primes vesicles independently of its MUN domain.

4. possible association of the dense-core vesicle secretion-related gene,CAPS2 (show CADPS2 Proteins) with autism specturum disorder. (review)

5. CAPS (show CAPS Proteins) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis

6. CAPS2 (show CADPS2 Proteins) promotes activity-dependent brain-derived neurotrophic factor (show BDNF Proteins) secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.

7. CAPS2 (show CADPS2 Proteins) KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders

8. These results demonstrate that the CAPS (show CAPS Proteins) family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 (show CADPS2 Proteins) is probably involved in BDNF (show BDNF Proteins) secretion in many brain areas.

9. CAPS2 (show CADPS2 Proteins)-mediated neurotrophin (show BDNF Proteins) release is indispensable for normal cerebellar development and functions, including neuronal differentiation and survival, morphogenesis, synaptic function, and motor learning/control.

10. In mouse, there are six splicing variants of CAPS2 (CAPS2a-f), and that these are subdivided into two groups: a long form containing the C-terminal Munc13-1-homologous domain (MHD) and a short form lacking the C-terminal MHD.