Calcyphosine 2 Proteins (CAPS2)

Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Calcyphosine 2 Antibodies (41) and Calcyphosine 2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CAPS2 84698 Q9BXY5
CAPS2 353025 Q8BUG5
CAPS2 366891  
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Top Calcyphosine 2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat CAPS2 Protein. 100 μg Log in to see 11 to 18 Days
Yeast Cynomolgus His tag   1 mg Log in to see 60 to 71 Days

CAPS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Calcyphosine 2 (CAPS2) Interaction Partners

Human Calcyphosine 2 (CAPS2) interaction partners

  1. These results indicate that LRRK2 and alpha-synuclein participate in the dysregulation of CADPS2 (show CADPS2 Proteins) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.

  2. Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2 (show CADPS2 Proteins)/D2DR (show DRD2 Proteins) interaction.

  3. We speculate that haploinsufficiency of CADPS2 (show CADPS2 Proteins) contributes to ASDs.

  4. identification, cloning, and comparative characterization of a second mammalian CAPS (show CAPS Proteins) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (show CAPS Proteins)

  5. Results from Cadps2 (show CADPS2 Proteins)-deficient mice and human data suggest that a disturbance in CADPS2 (show CADPS2 Proteins)-mediated neurotrophin (show BDNF Proteins) release contributes to autistic-like cellular and behavioral phenotypes.

  6. CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2

Mouse (Murine) Calcyphosine 2 (CAPS2) interaction partners

  1. that CAPS2 (show CADPS2 Proteins) deficiency strongly impairs hippocampal adult neurogenesis and maturation of newborn neurons

  2. These results suggest that Caps2 (show CADPS2 Proteins) KO mice have altered endocrine responses to CORT (show CORT Proteins) administration, while maintaining CORT (show CORT Proteins)-induced anxiety/depressive-like behavior.

  3. Naturally occurring splice variants of CAPS2 (show CADPS2 Proteins) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (show CADPS2 Proteins) primes vesicles independently of its MUN domain.

  4. possible association of the dense-core vesicle secretion-related gene,CAPS2 (show CADPS2 Proteins) with autism specturum disorder. (review)

  5. CAPS (show CAPS Proteins) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis

  6. CAPS2 (show CADPS2 Proteins) promotes activity-dependent brain-derived neurotrophic factor (show BDNF Proteins) secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.

  7. CAPS2 (show CADPS2 Proteins) KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders

  8. These results demonstrate that the CAPS (show CAPS Proteins) family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 (show CADPS2 Proteins) is probably involved in BDNF (show BDNF Proteins) secretion in many brain areas.

  9. CAPS2 (show CADPS2 Proteins)-mediated neurotrophin (show BDNF Proteins) release is indispensable for normal cerebellar development and functions, including neuronal differentiation and survival, morphogenesis, synaptic function, and motor learning/control.

  10. In mouse, there are six splicing variants of CAPS2 (CAPS2a-f), and that these are subdivided into two groups: a long form containing the C-terminal Munc13-1-homologous domain (MHD) and a short form lacking the C-terminal MHD.

Calcyphosine 2 (CAPS2) Protein Profile

Protein Summary

This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Calcyphosine 2 Proteins (CAPS2)

  • calcyphosine 2 (CAPS2)
  • calcyphosphine 2 (Caps2)
  • calcyphosine 2 (Caps2)
  • calcyphosine 2 (caps2)
  • calcium dependent secretion activator 2 (CADPS2)
  • CAPS2 protein
  • D630005B03Rik protein

Protein level used designations for Calcyphosine 2 Proteins (CAPS2)

calcyphosin-2 , calcyphosine-2 , calcyphosphine 2 , calcyphosin 2 , calcyphosine 2 , calcyphosin-2-like , CAPS-2 , Ca2+-dependent activator protein for secretion 2 , calcium-dependent activator protein for secretion 2 , calcium-dependent secretion activator 2

84698 Homo sapiens
353025 Mus musculus
366891 Rattus norvegicus
417859 Gallus gallus
467074 Pan troglodytes
481169 Canis lupus familiaris
524599 Bos taurus
100229458 Taeniopygia guttata
100380015 Xenopus (Silurana) tropicalis
100386560 Callithrix jacchus
93664 Homo sapiens
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