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The protein encoded by CTAG1B is an antigen that is overexpressed in many cancers but that is also expressed in normal testis.
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In 22 melanoma patients with stage III lymph node metastasis, overall survival was significantly higher in the XAGE-1b and NY-ESO-1 double-negative group than in the other groups.
The present results indicate the strong humoral immune response against NY-ESO-1 in natural human T-cell leukemia virus type 1 infection, irrespective of the clinical status.
some autoantibodies, such as anti-MAGEA4, anti-CTAG1 or anti-TP53 (show TP53 ELISA Kits) and their combinations could possibly contribute to the development of cancer early detection tests (not necessarily restricted to gastric cancer) when being combined with other markers.
High NY-ESO-1 expression is associated with Lung Cancer.
Results support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas.
Data suggest that only a small fraction of HLA-A*02:01- (HA)-binding ESO peptides are immunogenic, namely those that have high peptide-binding strength and peptide/HA complex stability. This study involved comparison of in silico-predicted and observed cytotoxic T-lymphocyte recognition of tumor antigen epitopes in melanoma patients and transgenic/knockout mice. (ESO = tumor antigen NY-ESO-1)
These data demonstrate that MAGE-A1-, MAGE-A3-, and NY-ESO-1-specific T cells with antigen-specific cytotoxicity can be cultured from healthy donors and patient-derived cells making adoptive immunotherapy with these cytotoxic T lymphocyte feasible.
Comparing the overall expression of CTAs, a decreased expression of all melanoma-associated (show ZNF654 ELISA Kits) antigens (MAGEs) post-treatment and a slightly increased expression of New York esophageal squamous cell carcinoma 1 (NY-ESO-1) was visible. The simultaneous cytoplasmic and nuclear expression of pan-MAGE or MAGE-A3/A4 correlated with reduced treatment-failure-free-survival (TFFS).
MAGE-A is more highly expressed than NY-ESO-1 in a majority of human malignancies
These cells were used to target a human lung cancer line that expressed NY-ESO-1.
The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence.
New York esophageal squamous cell carcinoma 1
, autoimmunogenic cancer/testis antigen NY-ESO-1
, cancer antigen 3
, cancer/testis antigen 1
, cancer/testis antigen 6.1
, l antigen family member 2