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CDX1 is a member of the caudal-related homeobox transcription factor gene family.
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XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR (show MLXIP Proteins)-155/CDX1 axis. caudal-type homeobox 1 (CDX1) was identified as a direct target of miR (show MLXIP Proteins)-155 and miR (show MLXIP Proteins)-155/CDX1 rescued the effects of XIST in breast cancer cells.
Results identified CDX1 as cis (show CISH Proteins) methylation quantitative trait loci in allergic rhinitis.
Downregulation of CDX1 is associated with recurrence in hepatocellular carcinoma.
Data indicate an association between highly fucosylated glycans and caudal type homeobox 1 (CDX1) and/or villin mRNA expression that both correlate with cell differentiation.
Changes in CDX1/CDX2 (show CDX2 Proteins) mRNA expression in gastric mucosa following H. pylori eradication showed only insignificant results
miR (show MLXIP Proteins)-215 is a link between CDX1 expression and BMI1 (show BMI1 Proteins) repression that governs differentiation in colorectal cancer
CDX1 restricts the invasion of HTR (show F2R Proteins)-8/SVneo trophoblast cells by inhibiting MMP-9 (show MMP9 Proteins) expression independently of the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.
Results showed an anti-growth effect of CDX1 and identified its miRNA regulatory mechanism in gastric cancer.
Certain SNPs of Cdx1 and Cdx2 (show CDX2 Proteins) and their interactions with other risk factors are associated with Barrett's esophagus (BE) and may contribute to human susceptibility to BE.
The differential regulation of the gene expression of CDX1, CDX2 (show CDX2 Proteins) and SOX2 (show SOX2 Proteins) in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.
Cdx1-Cdx2 (show CDX2 Proteins) double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (show ADCY10 Proteins) and a block in hematopoietic differentiation from yolk sac (show ADCY10 Proteins)-derived cells in culture.
transient expression of CDX1 promotes epicardial EMT (show ITK Proteins), whereas subsequent down-regulation of CDX1 after 11.5 dpc in mice is necessary for further subepicardial invasion of EPDCs and contribution to coronary vascular endothelium or smooth muscle cells.
These findings underscore previously unrecognized roles for Cdx members in intestinal tumorigenesis
we found that relative to Cdx1, Cdx2 (show CDX2 Proteins) was significantly less potent at effecting a transcriptional response from the Cdx1 promoter, a known Cdx target gene.
study is the first example of Cdx-Hox protein (show HOXA13 Proteins) interactions and suggests that such complexes may modulate Hox (show MSH2 Proteins) and/or Cdx function
SALL4 (show SALL4 Proteins) and KLF5 (show KLF5 Proteins) were aberrantly expressed in the CDX1(+) intestinal metaplasia of the stomach. Sustained expression of CDX1 gave rise to the induction of early intestinal-stemness markers, followed by the expression of intestinal-differentiation markers.
Cdx1 regulation on HoxC8 (show HOXC8 Proteins) expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox (show MSH2 Proteins) sequential activation.
The findings suggested that Cdx2 (show CDX2 Proteins) is essential for differentiation of the small intestinal epithelium, and that both Cdx1 and Cdx2 (show CDX2 Proteins) contribute to homeostasis of the colon.
Cdx members operate upstream of Dll1 (show DLL1 Proteins) to convey different functions in both somitogenesis and Goblet cell differentiation.
Data suggest that cdx proteins affect cardiogenesis by regulating the formation of cardiogenic mesoderm.
Oct3/4 (show POU5F1 Proteins) initiates its own negative autoregulation through Cdx1 up-regulation to begin the repression of pluripotency in preparation for the onset of gastrulation and germ layer differentiation.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.
caudal type homeobox 1
, caudal type homeobox transcription factor 1
, caudal type homeo box transcription factor 1
, caudal-type homeobox protein 1
, homeobox protein CDX-1
, caudal-type homeobox protein CDX1
, caudal type homeo box 1
, caudal-type homeodomain protein A
, homeobox protein CHOX-CAD