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human homolog may play a role in regulation of transcription and splicing [RGD, Feb 2006].. Additionally we are shipping Cdc2-Related Kinase, Arginine/serine-Rich Antibodies (46) and Cdc2-Related Kinase, Arginine/serine-Rich Kits (11) and many more products for this protein.
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Cdk12 suppresses genes that support metabolic functions in stressed conditions. Cdk12 is not a generally essential Pol II kinase and is not required for the transcription of essential and housekeeping genes at least in adult tissues.
CDK12 plays a role in controlling the epigenetic transition between euchromatin and heterochromatin, suggesting a chromatin regulatory mechanism in neuronal behaviors.
The phosphorylation of the C-terminal domain of the RNA polymerase II by Cdk12 provides an elegant mechanism in regulating timed splicing of newly synthesized mRNA molecules.
CDK12 regulates prereplicative complex assembly to promote mammalian cell proliferation.
CDK12 gene amplification can contribute to the pathogenesis of breast cancer.
BRCA1 downregulation combined with CHK1 inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 inhibition as a strategy for targeting BRCA1- or CDK12-deficient tumors.
In Ovarian Cancer patients CDK12 loss is consistently associated with a particular genomic instability pattern characterized by hundreds of tandem duplications
Structures of CDK12/CycK complexes solved in the presence of AMP-PNP.
Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12)/cyclin K (CycK) complex, rendering the kinase inactive.
CDK12 affects RNA processing events in two distinct ways: Indirectly through generating factor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specific factors
CDK12 and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response.
CDK12 plays an important role in cotranscriptional processing of c-FOS transcripts
CDK12 has properties that should confirm interest in its use as a biomarker.
many CDK12 mutations are an unrecognized cause of HR defects in ovarian cancers
CDK12 interacts with cyclin K and is required to maintain embryonnic stem cell self-renewal.
Cyclin K1 is the primary cyclin partner for CDK12/CrkRS and it is required for activation of CDK12/CrkRS to phosphorylate the C-terminal domain of RNA Pol II.
through regulation of expression of DNA damage response genes, CycK/Cdk12 protects cells from genomic instability
Data show that siRNA knockdown of hCDK12 in HeLa cells results in alterations in the CTD phosphorylation state.
CRK7 modifies MAP kinases regulation and resistance to estrogen signaling inhibitors in breast cancers.
Spontaneous DNA damage was revealed by an increase in 53BP1 foci among cells cultured from Cdk12(-/-) embryos.
Report on the functions of Cdk12 during neural development in vivo, proposes a dual role for Cdk12 in neurogenesis and late stage neuronal migration via 2 distinct pathways
The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
human homolog may play a role in regulation of transcription and splicing
, Cdc2-related kinase, arginine/serine-rich
, CDC2-related protein kinase 7
, cell division cycle 2-related protein kinase 7
, cell division protein kinase 12
, CDC2-related kinase 7
, CDC2-related kinase, arginine/serine-rich
, protein kinase for splicing component
, cyclin-dependent kinase 12 isoform
, cyclin-dependent kinase 12
, Cell division protein kinase 12