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The protein encoded by CDC34 is a member of the ubiquitin-conjugating enzyme family. Additionally we are shipping and many more products for this protein.
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Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp (show ASIP Proteins) residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis.
ubiquitin binding by the acidic loops of Ube2g1 (show Ube2g1 Proteins) and Ube2r1 enzymes distinguishes their Lys (show LYZ Proteins)-48-ubiquitylation activities
We discuss how these results can explain the rapid association of Cdc34 and SCF (show KITLG Proteins).
Here we have investigated how the acidic loop in human Cdc34 promotes ubiquitination, identifying two key molecular events during which the acidic loop exerts its influence
These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
Tristetraprolin (show ZFP36 Proteins) promotes an increase in expression of mature let-7, which leads to the inhibition of let-7 target gene CDC34 expression and suppresses cell growth.
Data show that anaphase-promoting complex or cyclosome (APC (show APC Proteins)/C)-mediated multiple monoubiquitylation targeting cyclin B1 (show CCNB1 Proteins) for degradation.
work provides the first structural details that show how the C-terminus of CDC34 might direct a thiolester-bound Ub to control polyubiquitin (show UBB Proteins) chain formation
the human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF (show KITLG Proteins)-dependent ubiquitination
COP9 (show COPS8 Proteins) signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP (show BTRC Proteins))-mediated degradation
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.
, cell division cycle 34 homolog
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, ubiquitin-conjugating enzyme E2-32 kDa complementing
, ubiquitin-conjugating enzyme E2-CDC34
, ubiquitin-protein ligase R1
, ubiquitin carrier protein
, ubiquitin-conjugating enzyme E2-32 KDA complementing
, serine protease