Cellular Retinoic Acid Binding Protein 1 Proteins (CRABP1)

Human Cellular Retinoic Acid Binding Protein 1 (CRABP1) interaction partners

1. We conclude that the underexpression of CRABP1 and the overexpression of LCN2 may be useful diagnostic biomarkers in thyroid tumours with questionable malignity, and the overexpression of LCN2 and C1QL1 may be useful for prognostic purposes.

2. Holo-CRABPs had higher affinity for CYP26B1 than free atRA, but both apo-CRABPs(CRABP-I and CRABP-II ) inhibited the formation of 4-OH-RA by CYP26B1.

3. p75NTR and CRABP1 modulate the effect of fenretinide on neuroblastoma cells

4. miR-93/miR-106b/miR-375-CIC-CRABP1 is a novel key regulatory axis in prostate cancer progression

5. CRABP1 expression is maintained in ER- and triple-negative breast tumors, and that elevated levels of CRABP1 is a significant indicator of high tumor grade, Ki67 immunoreactivity, and poor prognosis.

6. the first evidence of pro-tumorigenic and pro-metastatic activity of CRABP1 in mesenchymal and neuroendocrine tumors.

7. we demonstrated significant changes in CRABP1 and CRABP2 expression in non-small cell lung cancer samples

8. Factors involved in the retinoid pathway, in particular upregulation of CRBP, CRABP1 and CRABP2, also showed differential expression in tumors with different histological subtypes

9. Results describe the mRNA expression of CRABP1, RERG, and GRP in pituitary adenomas.

10. reduced expression of CRABP1 has a potential as a prognostic marker for serous adenocarcinoma which is the most frequent histological ovarian tumor type and also for clear cell carcinoma that often exhibits chemo-resistance.

11. Loss of cellular retinoic acid binding protein 1 function due to hypermethylation of its promoter leads to pathogenesis of papillary thyroid carcinoma

12. CSF of Moyamoya Disease [MMD] patients reveals high CRABP-I expression suggesting that the elevation of CRABP-I in CSF may be a candidate for pathogenesis of MMD

13. CRABP I plays an important role not only in mediating the retinoid effects, but also in modulating the radiation sensitivity of tumour cells after combined retinoic acid radiation treatment.

14. increased CYP26-mediated catabolism of retinoic by CRABP-I transfection might decrease the amount of retinoic acid that is accessible to the nuclear receptors

15. Decreases in the CRABP1 (cellular retinoic acid binding protein 1) and TFF3 (trefoil factor 3) expression levels identified these as candidate molecular biomarkers for papillary thyroid carcinoma.

16. Real-time RT-PCR analysis disclosed a significant lack of CRABP-I expression in four renal cell carcinoma cell lines

17. Hypermethylation was subsequently identified for three of four analyzed genes, ADAMTS1 (85%), CRABP1 (90%), and NR3C1 (35%).

18. Frequent methylation-associated silencing of CRABP1 is associated with esophageal squamous-cell carcinoma

19. DNA hypermethylation of tumour suppressor genes seems to play an important role in ovarian carcinogenesis and HOXA9, HOXB5, SCGB3A1, and CRABP1 are identified as novel hypermethylated target genes in this tumour type

20. As epidermal basal keratinocyte proliferation is stimulated by paracrine growth factors secreted by ATRA activated suprabasal keratinocytes, our results indicate that CRABPI overexpression in suprabasal keratinocytes enhances ATRA.

Pig (Porcine) Cellular Retinoic Acid Binding Protein 1 (CRABP1) interaction partners

1. Chromosome mapping of CRABP1 AND CRABP2 in swine.

Mouse (Murine) Cellular Retinoic Acid Binding Protein 1 (CRABP1) interaction partners

1. This is the first report of a physiological role of cellular retinoic acid binding protein I( CRABP)1 as an endogenous regulator of calcium-calmodulin protein kinase II, which protects the heart from isoproterenol-induced damage.

2. The physiological role of Crabp1 in modulating stem cell proliferation and hippocampus-dependent brain activities such as learning and memory.

3. This study reveals a physiological relevance of the non-genomic action of atRA, mediated by Crabp1, in modulating cell cycle progression and apoptosis induction

4. Only a small fraction of CRABP1 populates this functionally important but vulnerable conformation of CRABP1, enabling efficient ligand binding.

5. CRABPI binds to all-trans retinoic acid in the cytoplasm, resulting in rapid ERK1/2 activation that is independent of membrane signal and nuclear RA receptors.

6. These data suggest that CRABPI functions to regulate the intracellular concentrations of retinoic acid and to maintain high levels of oxidized retinoic acid metabolites such as 4-oxoretinoic acid within cells.

7. The expression of CRABP I in the embryonic cerebellum coincides with earliest cerebellar differentiation; its involvement in a complex network of regulatory genes expressed in the mes/methencephalon is discussed in this review.

8. This study presents the first evidence that over-expressed receptor interacting protein 140 acts as a thyroid hormone (T3)-dependent negative co-regulator for T3 induction of the endogenous cellular retinoic acid binding I protein gene in P19 cells.

9. proline isomerization may not be responsible for the slowest folding phase of CRABP I so the loss of a slow refolding phase upon mutation may not be diagnostic for proline isomerization effects on protein folding

10. Increases in CRABPI and II transcripts in the absence of leukemia inhibitory factor may regulate aspects of embryonic stem cell differentiation in response to retinol.

Zebrafish Cellular Retinoic Acid Binding Protein 1 (CRABP1) interaction partners

1. subfunctionalization may be the mechanism for the retention of both crabp1 duplicated genes in the zebrafish genome