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The product of CEP170 is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Additionally we are shipping CEP170 Antibodies (27) and and many more products for this protein.
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Cep170 interacts with Polo-like kinase 1 in mature centrioles [Cep170]
Data suggest that CDK5RAP2 and CEP170 both interact with microtubule nucleation-promoting region of AKAP350A; CEP68 interacts with distal C-terminal region of AKAP350A; AKAP350A spans the bridge between centrioles. (CDK5RAP2 = CDK5 regulatory subunit associated protein 2; CEP170 = centrosomal protein 170kDa; AKAP350A = A kinase (PRKA) anchor protein (yotiao) 9; CEP68 = centrosomal protein 68kDa)
Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle.
Cep170 interacts with Polo-like kinase 1 in mature centrioles.
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.
KARP-1 binding protein 1
, centrosomal protein 170kDa
, centrosomal protein of 170 kDa
, KARP-1-binding protein
, centrosomal protein of 170 kDa-like
, XRCC5 binding protein