Ceramide Synthase 2 Proteins (CERS2)

CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Additionally we are shipping Ceramide Synthase 2 Antibodies (56) and Ceramide Synthase 2 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CERS2 29956 Q96G23
CERS2 76893 Q924Z4
Rat CERS2 CERS2 310667  
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Top Ceramide Synthase 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

CERS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Ceramide Synthase 2 (CERS2) Interaction Partners

Human Ceramide Synthase 2 (CERS2) interaction partners

  1. ASGR1 (show ASGR1 Proteins) can inhibit the activity of V-ATPase (show ATP6V1H Proteins) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.

  2. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) inhibit cell growth by regulating expression of KLF4/LASS2/V-ATPase proteins in breast cancer.

  3. these results indicate that miR (show MLXIP Proteins)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (show MLXIP Proteins)-9 promotes chemoresistance of bladder cancer cells by target LASS2.

  4. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.

  5. silencing of TMSG1 increased V-ATPase (show ATP6V1H Proteins) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (show MMP2 Proteins), which ultimately promoted metastasis capacity of breast cancer cell.

  6. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (show CASP3 Proteins)-dependent mitochondrial pathway.

  7. the vacuolar ATPase (V-ATPase) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (show MMP2 Proteins)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1

  8. the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells

  9. Co-expression of CerS2 with CerS4 (show CERS4 Proteins)/CerS6 (show CERS6 Proteins) reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  10. expression and role of ceramide synthase-2 in the lung

Mouse (Murine) Ceramide Synthase 2 (CERS2) interaction partners

  1. LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.

  2. Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (show TJP1 Proteins) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.

  3. this study shows that Cers2 limits the levels of S1P (show S1PR1 Proteins) in thymus and blood to maintain functional S1P (show S1PR1 Proteins) gradients that mediate thymocyte emigration into the circulation

  4. that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (show CERS1 Proteins) mutant mouse brains.

  5. CerS1 (show CERS1 Proteins), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 Proteins)-null mice.

  6. Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.

  7. Development of pheochromocytoma in ceramide synthase 2 null mice

  8. our data strongly indicate that G-CSF (show CSF3 Proteins)-induced CXCR2 (show CXCR2 Proteins) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.

  9. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (show TNF Proteins)) secretion as a result of enhanced activity of TNFalpha (show TNF Proteins)-converting enzyme (TACE (show ADAM17 Proteins)).

  10. CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio

Ceramide Synthase 2 (CERS2) Protein Profile

Protein Summary

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Gene names and symbols associated with Ceramide Synthase 2 Proteins (CERS2)

  • ceramide synthase 2 (CERS2)
  • ceramide synthase 2 (Cers2)
  • 0610013I17Rik protein
  • AI225939 protein
  • L3 protein
  • Lass2 protein
  • SP260 protein
  • TMSG1 protein
  • TRH3 protein

Protein level used designations for Ceramide Synthase 2 Proteins (CERS2)

LAG1 homolog, ceramide synthase 2 , LAG1 longevity assurance 2 , longevity assurance (LAG1, S. cerevisiae) homolog 2 , tumor metastasis-suppressor gene 1 protein , LAG1 longevity assurance homolog 2 , TRAM homolog 3 , longevity assurance homolog 2 , translocating chain-associating membrane protein homolog 3

100055037 Equus caballus
29956 Homo sapiens
483187 Canis lupus familiaris
539223 Bos taurus
76893 Mus musculus
310667 Rattus norvegicus
100156737 Sus scrofa
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