Ceramide Synthase 6 (CERS6) ELISA Kits

Human Ceramide Synthase 6 (CERS6) interaction partners

1. ceramide synthase (CerS)6 was specifically up-regulated in zone 3 hepatocytes in alcoholic steatosis

2. This study has shown that by direct transcriptional activation of CerS6, p53 (show TP53 ELISA Kits) can regulate specific ceramide biosynthesis, which contributes to the pro-apoptotic cellular response.

3. silencing of CerS6 induced the increased expression of GLUT1 (show SLC2A1 ELISA Kits), which downregulated the expression of WNT5A (show WNT5A ELISA Kits) and enhanced the invasion and proliferation of melanoma cells.

4. Identification of CerS6 and ceramide pathways as a novel Methotrexate target.

5. stichoposide D inhibits growth of experimental leukemia by activating Fas (show FAS ELISA Kits)/ceramide synthase 6/p38 (show CRK ELISA Kits) kinase in lipid rafts

6. CERS6-dependent ceramide synthesis and maintenance of ceramide in the cellular membrane are essential for lamellipodia formation and metastasis.

7. Data indicate that ceramide synthase 6 (CerS6) expression is upregulated in leukocytes from multiple sclerosis (MS) patients.

8. On the basis of its pivotal role in regulating cell death upon COX dysfunction, CerS6 might potentially represent a novel target for therapeutic intervention in mitochondrial diseases caused by COX dysfunction.

9. Taken together, these results suggest that increased expression of CerS6 can mediate transcriptional activation of acid ceramidase (show ASAH1 ELISA Kits) in a JNK (show MAPK8 ELISA Kits)-dependent manner that is independent of CerS6 activity.

10. CerS6 as a novel epithelial-mesenchymal transition-regulated gene that has a pivotal role in the regulation of cell migration.

Mouse (Murine) Ceramide Synthase 6 (CERS6) interaction partners

1. ceramide synthase (CerS)6 was specifically up-regulated in experimental alcoholic steatosis in vivo and in vitro

2. CerS1, -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (show SIRT3 ELISA Kits)-null mice.

3. CerS6 deletion increases energy expenditure and improves glucose tolerance, not only in CerS6(Delta/Delta) mice, but also in brown adipose tissue- (CerS6(DeltaBAT)) and liver-specific (CerS6(DeltaLIVER)) CerS6 knockout mice.

4. Data show that ceramide synthase 6 knockout (CerS6KO) experimental autoimmune encephalomyelitis (EAE) mice exhibit exacerbated progression of clinical symptoms.

5. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1-Cers6) activity in macrophages is responsible for the accumulation of ceramide.

6. CerS6 protein is N-glycosylated and expressed in several tissues of mice, mainly kidney, small and large intestine, and brain.

7. An important role is revealed for C16:0-Cer (show CBLN1 ELISA Kits) (ceramide synthase 6) in the inflammatory process and subsequently in the induction of experimental autoimmune encephalitis.

8. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6 (show ATF6 ELISA Kits)-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2 (show CA2 ELISA Kits)+ and ER/Golgi membrane network