anti-Chemokine (C-C Motif) Ligand 22 (CCL22) Antibodies

CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Additionally we are shipping CCL22 Proteins (64) and CCL22 Kits (42) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCL22 6367 O00626
CCL22 20299 O88430
CCL22 117551  
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Top anti-CCL22 Antibodies at antibodies-online.com

Showing 10 out of 164 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of CCL22 using HT29 whole  lysates. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 to 16 Days
$222.00
Details
Mouse Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Mouse Spleen lysate; Primary Ab: 5µg/ml Rabbit Anti-Mouse MDC Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 13 to 16 Days
$228.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Rat Tissue 100 μg 13 to 16 Days
$342.00
Details
Dog Rabbit Un-conjugated ICC, IHC, WB 100 μg 13 to 16 Days
$360.00
Details
Cow Rabbit Un-conjugated ICC, IHC, WB 100 μg 13 to 16 Days
$378.00
Details
Mouse Rabbit Un-conjugated IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded rat lung, Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with	Rabbit Anti-ABCD1/CCL22 Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary for 90 minutes and DAB staining. 100 μL 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated Neut, ELISA, WB 100 μg 11 to 14 Days
$493.17
Details
Mouse Rabbit Un-conjugated Neut, ELISA, WB 100 μg 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat kidney using CCL22 antibody at dilution of 1:100 (40x lens). Immunohistochemistry of paraffin-embedded human colon using CCL22 antibody at dilution of 1:100 (40x lens). 100 μL 11 to 13 Days
$366.77
Details

Top referenced anti-CCL22 Antibodies

  1. Human Monoclonal CCL22 Primary Antibody for FACS - ABIN4896920 : Mizukami, Kono, Kawaguchi, Akaike, Kamimura, Sugai, Fujii: CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. in International journal of cancer 2008 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal CCL22 Primary Antibody for Func, ELISA - ABIN2475544 : Imai, Chantry, Raport, Wood, Nishimura, Godiska, Yoshie, Gray: Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 Pubmed References

More Antibodies against CCL22 Interaction Partners

Human Chemokine (C-C Motif) Ligand 22 (CCL22) interaction partners

  1. In oral cancer specimens, CCL22 mRNA was upregulated. Release of IL-1beta from cancer-associated fibroblasts (CAF) induces CCL22 mRNA expression in oral cancer cells by activating NF-kappaB. Data support a model in which CAF-derived IL-1beta, CCL22, and its receptor CCR4 foster a protumor environment by promoting cell transformation and Treg infiltration.

  2. Th2-associated chemokine CCL22 levels appear to be inversely related to mite sensitization and the risk of asthma development in early childhood.

  3. The frequency of CC genotypes at both SNPs rs4359426 and rs2228428 in C-C motif chemokine 22 (CCL22) and chemokine (C-C motif) receptor 4 protein (CCR4) genes was significantly higher in myocardial infarction (MI) patients compared to other genotypes.

  4. High level of CCL22 is associated with histamine receptor 2 stimulation and thus atherosclerosis.

  5. Both CCL1 and CCL22 were expressed in most breast cancer tissues. CCL1 was significantly over-expressed in invasive breast cancer as compared to normal breast tissue. CCL1, but surprisingly not CCL22, showed a significant correlation with the number of tumor-infiltrating FoxP3+ Treg

  6. This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4, CCL17, and CCL22 in experimental autoimmune encephalomyelitis pathogenesis. [review]

  7. MDC might serve as a marker of pharmacological therapy response in major depressive disorder

  8. Data suggest that high levels of CCL17 and CCL22 in endometrium in women with endometriosis promote (1) recruitment of Tregs, (2) immunosuppression of Tregs, and (3) angiogenesis in endometrium. (Tregs = regulatory T cells)

  9. blood CCL22 levels were positively associated with IgE sensitization at age 2. A high cord blood CCL22/CXCL10 chemokine ratio was significantly associated with a higher risk of allergic sensitization at age 3.

  10. Tumor-associated macrophages promote prostate cancer migration through activation of the CCL22-CCR4 signaling axis.

  11. Elevations in serum MDC and BLC were independently associated with the significant risk of early stage lung adenocarcinoma, even in non-smokers and in stage IA patients.

  12. These results showed that the higher levels of CXCL10, CCL20 and CCL22 were associated with ischemic heart disease. The serum levels of chemokines may influence by the certain traditional risk factors of IHD and some studied SNPs, but did not influence by treatment and gender of patients.

  13. CCL22 plays an important role in supporting gastric cancer development presumably by increasing the percentage of regulatory T cells in the tumor microenvironments. CCL22 levels in sera have a predictive value for gastric cancer peritoneal metastasis and the early recurrence.

  14. The CCL22-mediated enhancement of antitumor responses is however not due to conversion, but rather to redirection of existing regulatory T cells to the site of cutaneous overexpression.

  15. CCL22 and IL-37 with a co-localization in non-small cell lung cancer A549 cells inhibited the proliferation and epithelial-mesenchymal transition process

  16. Data suggest that Th1 (IFN-gamma-inducible protein-10 IP-10/CXCL10) and Th2 (thymus and activation regulated chemokine TARC/CCL17) and (macrophage derived chemokine MDC/CCL22) cooperatively play a role in the development of ankylosing spondylitis (AS).

  17. increased amounts released by neutrophils from fibromyalgia patients

  18. Our results demonstrate that CCL22 is expressed in human placenta. Decidual expression was only observed in miscarriage conditions and correlates with Treg infiltration.

  19. Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris.

  20. type I IFN blocks the regulatory T cell-attracting chemokine CCL22 and thus helps limit the recruitment of regulatory T cells to tumors

Mouse (Murine) Chemokine (C-C Motif) Ligand 22 (CCL22) interaction partners

  1. the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis

  2. Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth.

  3. this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells

  4. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function.

  5. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells

  6. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators

  7. CCL22 has a role in Treg skin homing to suppress depigmentation

  8. CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation

  9. The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders.

  10. Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent.

  11. islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell

  12. Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices.

  13. These results suggest that CCL22 functions to regulate development of experimental autoimmune encephalomyelitis through macrophage chemoattraction and effector function.

  14. role of CCL22 for the recruitment of eosinophils during allergic pleurisy

  15. functionally increased expression during Salmonella enterica serovar Typhimurium infection of dendritic cells

  16. Regulatory elements of the CCL22 gene required to mediate a strong and highly specific expression are included in a 4.1-kb promoter region, with the major elements active in dendritic cells and B cells being located in a small proximal 250-bp region.

  17. CCL22 was selectively upregulated in osteoclast-like cells derived from RAW264.7 cells and mouse bone marrow cells upon stimulation with RANKL (receptor activator of nuclear factor-kappaB ligand).

  18. study provides direct evidence for the presence of CCR4 and its ligands, CCL17 and CCL22, in mouse contact hypersensitivity

  19. IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation.

  20. When isolated, only natural killer (NK)-containing cellular fractions secrete CCL22, and the same fraction isolated from metastatic Lewis lung carcinoma (LLC)-bearing lungs secrete higher levels.

CCL22 Antigen Profile

Protein Summary

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.

Gene names and symbols associated with CCL22

  • C-C motif chemokine ligand 22 (CCL22) antibody
  • chemokine (C-C motif) ligand 22 (Ccl22) antibody
  • C-C motif chemokine ligand 22 (Ccl22) antibody
  • ABCD-1 antibody
  • CCL22 antibody
  • DC/B-CK antibody
  • DCBCK antibody
  • Mdc antibody
  • Scya22 antibody
  • STCP-1 antibody

Protein level used designations for CCL22

C-C motif chemokine 22 , CC chemokine STCP-1 , MDC(1-69) , macrophage-derived chemokine , small inducible cytokine A22 , small inducible cytokine subfamily A (Cys-Cys), member 22 , small-inducible cytokine A22 , stimulated T cell chemotactic protein 1 , stimulated T-cell chemotactic protein 1 , CC chemokine ABCD-1 , SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED) , activated B and dendritic cell-derived , dendritic cell and B cell derived chemokine , small inducible cytokine subfamily A, member 22 , small inducible cytokine subfamily A22 , small inducible cytokine subfamily A (Cys-Cys) member 22 , chemokine (C-C motif) ligand 22

GENE ID SPECIES
6367 Homo sapiens
20299 Mus musculus
117551 Rattus norvegicus
616996 Bos taurus
736543 Pan troglodytes
100686212 Canis lupus familiaris
100516016 Sus scrofa
100716085 Cavia porcellus
101123141 Ovis aries
103348469 Oryctolagus cuniculus
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