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CCL28 belongs to the subfamily of small cytokine CC genes. Additionally we are shipping CCL28 Proteins (55) and CCL28 Kits (31) and many more products for this protein.
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Results identified chemotactic and antimicrobial properties of bCCL28 indicating that this chemokine (show CCL1 Antibodies) may contribute to immune protection of the mammary gland, and the resolution or prevention of bovine mastitis.
this review discusses the role of CCL28 (show ENC1 Antibodies) in innate and adaptive immunity
Results show that CCL28 (show ENC1 Antibodies) expression was up-regulated under hypoxic condition in lung adenocarcinoma cells. Besides other effects on tumor biology such as immunosuppression, CCL28 (show ENC1 Antibodies) could promote angiogenesis in lung adenocarcinoma by directly activating its receptor, CCR3 (show CCR3 Antibodies), on microvascular endothelial cells.
our results show for the first time that CCL28 (show ENC1 Antibodies) contributes to breast cancer progression through the ERK (show EPHB2 Antibodies)/MAPKmediated anti-apoptotic and metastatic signaling pathway. Antagonists of CCL28 (show ENC1 Antibodies) and the MAPK (show MAPK1 Antibodies) signaling pathway may be used synergistically to treat breast cancer patients.
HCC (show FAM126A Antibodies) recruits Tregs to promote angiogenesis under hypoxic condition by upregulating CCL28 (show ENC1 Antibodies) expression. These findings establish a link between Tregs and hypoxia in HCC (show FAM126A Antibodies) growth and may provide a new potential therapeutic target for treating HCC (show FAM126A Antibodies).
CCL28 (show ENC1 Antibodies) was absent in saliva (show RAG1AP1 Antibodies) of primary Sjogren's syndrome patients. This finding did not correlate with salivary IgA (show IgA Antibodies) levels.
disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE
CCL28 (show ENC1 Antibodies)-CCR3 (show CCR3 Antibodies) interactions are involved in the homeostatic trafficking of CD4 (show CD4 Antibodies)(+) T cells to the upper airways.
High CCL28 (show ENC1 Antibodies) gene methylation is associated with gastric tumor aggressiveness.
CCL28 (show ENC1 Antibodies) is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells.
These results indicate a role for IL-17A in the human lung by enhancing the expression of CCL28 and hence driving the recruitment of IgE-secreting B cells.
Mucosae associated-epithelial chemokine (MEC/CCL28) cloned from porcine salivary gland and colon tissues consisted of an open reading frame (ORF) of 384-bp coding for 127 amino-acids protein with 22 residues signal sequence.
Plasmid codelivery of murine CCL19 (show CCL19 Antibodies) and CCL28 enhanced Ag-specific systemic and mucosal Ab responses to HIV-1 gp140, augmented balanced Th1 (show HAND1 Antibodies)/Th2 responses, and increased lymphocyte subsets in various lymphoid tissues.
These data suggest that CCL28 could be useful in enhancing the IgA (show IgA Antibodies) immune response that will likely play a pivotal role in prophylactic HIV vaccines.
tumour hypoxia promotes the recruitment of regulatory T (T(reg (show KCNH2 Antibodies))) cells through induction of expression of the chemokine (show CCL1 Antibodies) CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis
demonstrate that interactions between the antimicrobial C-terminus of CCL28 with an appropriate CC chemokine (show CCL1 Antibodies) N-terminal domain is important for the full antimicrobial activity of CCL28.
CCL28 has dual functions in mucosal immunity as a chemokine (show CCL1 Antibodies) attracting cells expressing CCR10 (show CCR10 Antibodies) and/or CCR3 (show CCR3 Antibodies) and also as an apically secreted molecule with a potent antimicrobial activity against a broad spectrum of microbes.
MEC attracts IgA- but not IgG- or IgM-producing plasmablasts from both intestinal and nonintestinal lymphoid and effector tissues, including the intestines, lungs, and lymph nodes draining the bronchopulmonary tree and oral cavity.
Epithelial cells and venular endothelium of both small intestine and colon are positive for CCL28; CCL28 plays a direct role in intestinal homing of IgA (show IgA Antibodies) antibody-secreting cells by mediating their extravasation into intestinal lamina propria.
CCL28 is a key regulator of IgA (show IgA Antibodies) ASC (show STS Antibodies) accumulation in the mammary gland and thus controls the passive transfer of IgA (show IgA Antibodies) antibodies from mother to infant.
CCL28 appears to play a role in regulating eosinophil recruitment to peribronchial regions of the lung possibly by coordinated temporal production with eotaxin
CCL28 mediates mucosal immunity in HIV exposure and infection
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs.
C-C motif chemokine 28
, CC chemokine CCL28
, chemokine ligand 28
, chemokine CCL28/MEC
, chemokine (C-C motif) ligand 28
, ectodermal-neural cortex (with BTB-like domain)
, ectoderm neural cortex related-3
, chemokine (C-C motif) ligand 28 splice variant chi
, mucosae-associated epithelial chemokine
, small inducible cytokine A28
, small inducible cytokine subfamily A (Cys-Cys), member 28
, small-inducible cytokine A28
, chemokine CCL28
, mucosae-associated epithelial chemokine CCL28
, CC chemokine ligand 28