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Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Additionally we are shipping CXCL16 Kits (91) and CXCL16 Proteins (49) and many more products for this protein.
Showing 10 out of 208 products:
Human Polyclonal CXCL16 Primary Antibody for CyTOF, ELISA (Capture) - ABIN4900386
Dieudonné, Torres, Blanchard, Taront, Jeannin, Delneste, Pichavant, Trottein, Gosset: Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA. in PLoS ONE 2012
Show all 8 Pubmed References
Mouse (Murine) Polyclonal CXCL16 Primary Antibody for CyTOF, FACS - ABIN4899997
Eberlein, Nguyen, Victorino, Golden-Mason, Rosen, Homann: Comprehensive assessment of chemokine expression profiles by flow cytometry. in The Journal of clinical investigation 2010
Show all 5 Pubmed References
Mouse (Murine) Polyclonal CXCL16 Primary Antibody for ELISA (Detection), FACS - ABIN4899996
Gough, Garton, Wille, Rychlewski, Dempsey, Raines: A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. in Journal of immunology (Baltimore, Md. : 1950) 2004
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Mouse (Murine) Polyclonal CXCL16 Primary Antibody for IF (p), IHC (p) - ABIN686572
Cottle, Ursino, Ip, Jones, Ditommaso, Hacking, Mangan, Mellett, Henley, Sviridov, Nold-Petry, Nold, Meikle, Kile, Smyth: Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. in Human molecular genetics 2014
Human Polyclonal CXCL16 Primary Antibody for EIA, IHC (p) - ABIN116406
Gutwein, Abdel-Bakky, Schramme, Doberstein, Kämpfer-Kolb, Amann, Hauser, Obermüller, Bartel, Abdel-Aziz, El Sayed, Pfeilschifter: CXCL16 is expressed in podocytes and acts as a scavenger receptor for oxidized low-density lipoprotein. in The American journal of pathology 2009
Show all 2 Pubmed References
Human Polyclonal CXCL16 Primary Antibody for EIA, IHC (p) - ABIN116405
Scholz, Schulte, Adamski, Hundhausen, Mittag, Schwarz, Kruse, Proksch, Ludwig: Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin. in The Journal of investigative dermatology 2007
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Human Monoclonal CXCL16 Primary Antibody for FACS - ABIN4897616
Reyat, Chimen, Noy, Szyroka, Rainger, Tomlinson: ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration. in Journal of immunology (Baltimore, Md. : 1950) 2017
CXCL16 increases the frequency of the miniature excitatory synaptic currents (mEPSCs) and reduces the PPR (show PTH1R Antibodies) of evoked excitatory transmission, indicating that the chemokine (show CCL1 Antibodies) also modulates and enhances the release of glutamate (show GRIN1 Antibodies).
results indicate that CXCL16 plays a key role in the pathogenesis of renal injury and fibrosis in salt-sensitive hypertension through regulation of bone marrow-derived fibroblast accumulation and macrophage and T cell infiltration.
Data indicate that chemokine (show CCL1 Antibodies) C-X-C ligand 16 (CXCL16) is a critical regulator of liver immune response to acetaminophen (APAP)-induced hepatotoxicity, suggesting a potential strategy for the treatment of drug-induced acute liver failure by targeting CXCL16.
CXCL16 plays a crucial role in the pathogenesis of cisplatin-induced acute kidney injury through regulation of apoptosis and inflammation.
These findings suggest that the CXCL16 gene product promotes inflammatory factors and cell infiltration factors, and inhibits the expression of antioxidant factors to accelerate the development of DN, and CXCL16 deficiency attenuates DN may be involved in the AKT (show AKT1 Antibodies) signaling pathway.
Results indicate that CXCL16 plays a pivotal role in the pathogenesis of renal artery stenosis-induced renal injury and fibrosis through regulation of bone marrow-derived fibroblast accumulation and macrophage and T-cell infiltration.
Simvastatin exerts a protective effect on renal function and structure in mice with ADR (show SARS Antibodies) nephropathy which related to the decreasing expression of CXCL16 in glomerular podocytes followed by the decreasing endocytosis of ox-LDL in podocytes and inhibition of NF-kappaB (show NFKB1 Antibodies) pathway activation.
These results indicate that MEK (show MDK Antibodies) inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC (show NPC1 Antibodies)-induced osteoclastogenesis via modulating CCL2 (show CCL2 Antibodies) and CXCL16 expressions.
Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy
injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD (show TSC2 Antibodies).
Enhanced CXCL16 expression in lung cancer tissue promoted the proliferation and invasion of lung cancer cells. CXCL16 might promote proliferation and invasion of lung cancer by regulating the NF-kappaB (show NFKB1 Antibodies) pathway.
increased plasma sCXCL16 might be implicated in the pathogenesis of immune thrombocytopenia and have a relationship with Th1 (show TH1L Antibodies)/Th2 imbalance.
Serum CXCL16 levels are significantly increased in patients with gallstone, and are independently associated with liver injury in Chinese population, suggesting that CXCL16 may be a biomarker of liver injury in subjects with gallstone or NAFLD (show TSC2 Antibodies). Hepatic CXCL16 mRNA and protein levels were also significantly increased in gallstone patients
IFN-gamma (show IFNG Antibodies), CXCL16 and uPAR (show PLAUR Antibodies) are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in systemic lupus erythematosus.
Data showed that reverse signaling via CXCL16 promotes migration in CXCL16-expressing melanoma and glioblastoma cells, but does not affect proliferation or protection from chemically-induced apoptosis.
Study showed, for the first time, highly significant relationships of circulating CXCL16 level with cardiac injury markers in dialysis patients.
Women with gestational diabetes mellitus and preeclampsia had a dysregulated CXC chemokine ligand 16 during pregnancy, and in gestational diabetes mellitus, the increase in CXC chemokine ligand 16 early in pregnancy and after 5 years was strongly associated with their lipid profile.
Data suggest that primary cells from papillary renal cell carcinoma (show MOK Antibodies) secrete the chemokines IL8 (show IL8 Antibodies), CXCL16, and chemerin (show RARRES2 Antibodies); these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 (show IL8 Antibodies) = interleukin-8 (show IL8 Antibodies); CXCL16 = C-X-C motif chemokine (show CCL1 Antibodies) ligand 16)
Our study demonstrated that CXCL16-CXCR6 (show CXCR6 Antibodies) mediates CD8 (show CD8A Antibodies)(+) T-cell skin trafficking under oxidative stress in patients with vitiligo (show MITF Antibodies), and CXCL16 expression in human keratinocytes induced by ROS (show ROS1 Antibodies) is, at least in part, caused by unfolded protein response activation
eGFR (show EGFR Antibodies) and serum albumin (show ALB Antibodies) had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease.
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
chemokine (C-X-C motif) ligand 16
, C-X-C motif chemokine 16
, Transmembrane chemokine CXCL16
, Cxc chemokine ligand 16
, scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
, small-inducible cytokine B16
, transmembrane chemokine CXCL16
, zinc finger, MYND-type containing 15
, CXC chemokine ligand 16