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The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Additionally we are shipping Chloride Channel 4 Proteins (4) and many more products for this protein.
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Human Polyclonal CLCN4 Primary Antibody for IF, ELISA - ABIN545347
Dinulos, Bassi, Rugarli, Chapman, Ballabio, Disteche: A new region of conservation is defined between human and mouse X chromosomes. in Genomics 1996
Show all 3 Pubmed References
In Mus spretus, the chloride channel 4 gene Clcn4-2 is X-linked and dosage compensated by X up-regulation and X inactivation, while in the closely related mouse species Mus musculus, Clcn4-2 has been translocated to chromosome 7.
Unique oligomerization properties of ClC-4 permit regulated targeting of ClC-4 to various endosomal compartment systems via expression of different ClC-3 splice variants.
This study performed whole exome sequencing demonistrated that the true de novo variants represent mutations in genes (KCNH5, CLCN4, and ARHGEF15) not previously associated with epilepsies in humans.
the voltage dependence of uncoupled ClC-4 by protons and anions
CLCN4 is a novel driver of colon cancer progression.
Studies showed that three novel CLC-5 mutations were identified, and mutations in OCRL1, CLC-4 and cofilin excluded in causing Dent's disease.
ClC-4 is an intracellular chloride channel that stimulates copper incorporation into ceruloplasmin, probably by improving the efficiency of the ATP7B copper pump.
coupled Cl-/H+ transport of ClC-4 and ClC-5 is of significant magnitude in vivo
crystal structure: CLIC4 appears to be able to form a redox-regulated ion channel in the absence of any partner proteins
A stretch of amino acids, residues 14-63, at the N-terminus constitutes a novel motif both necessary and sufficient for targeting hClC-4 and other membrane proteins to the endoplasmic reticulum.
The proposed mechanism results in anion-dependent conversion of ClC-type exchanger into an anion channel with typical attributes of ClC anion channels.
Vesicle acidification, exocytosis, endocytosis, and secretory pathway.
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins.
chloride channel 4
, H(+)/Cl(-) exchange transporter 4
, chloride channel protein 4
, chloride transporter ClC-4
, voltage-gated chloride channel ClC-4A
, chloride channel 4-2
, putative chloride channel (similar to Mm Clcn4-2)
, putative chloride channel 4-2