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May catalyze the formation of 25-hydroxycholesterol from cholesterol (By similarity).. Additionally we are shipping CH25H Antibodies (20) and CH25H Proteins (7) and many more products for this protein.
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We detected Cholesterol 25-hydroxylase, the enzyme responsible for 25-HC production, in human spermatozoa at the level of the neck and the post acrosomal area. Upon incubation with spermatozoa, 25-HC induced calcium and cholesterol transients in connection with the acrosomal reaction.
Exome analysis in 212 multiple sclerosis and 14 neuromyelitis optica patients identified a rare CH25H p.Q17H mutation in two NMO patients of Asian ancestry. In addition, association analysis of common CH25H variants.
Infection with HCV causes up-regulation of interferon (show IFNA ELISA Kits)-inducible CH25H in vivo.
These results demonstrate that CH25H constitutes a primary innate response against hepatitis C virus infection through regulating host lipid metabolism.
Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.
Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1 (show ABCA1 ELISA Kits)), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H (show CYP46A1 ELISA Kits)).
Adenovirus-mediated Ch25h overexpression in mice improved glucose tolerance and insulin (show INS ELISA Kits) sensitivity and lowered HOMA-IR. Our data suggest that low hepatic Ch25h levels could be considered a risk marker for unhealthy obesity.
Ch25h-deficient mice exhibit increased sensitivity to septic shock, exacerbated experimental autoimmune encephalomyelitis, and a stronger ability to repress bacterial growth.
Disruption of Roralpha1 (show RORA ELISA Kits) and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Roralphasg/sg mice.
Findings indicate that CYP7B1 (show CYP7B1 ELISA Kits) and HSD3B7, as well as CH25H, have essential roles in controlling oxysterol production in lymphoid tissues.
We found that expression of Ch25h is upregulated following L. monocytogenes infection
Data show that The increased Ch25h expression was dependent on Toll-like receptor 4 (show TLR4 ELISA Kits) signaling.
deletion of the mouse cholesterol 25-hydroxylase gene caused an increase in serum IgA (show IgA ELISA Kits).
Collectively, these findings demonstrate that CH25H is an intrinsic host restriction factor in pseudorabies virus infection of porcine alveolar macrophages.
May catalyze the formation of 25-hydroxycholesterol from cholesterol (By similarity).
, cholesterol 25-hydroxylase-like protein
, cholesterol 25-monooxygenase