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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Muscarinic Acetylcholine Receptor M2 Antibodies (178) and Muscarinic Acetylcholine Receptor M2 Proteins (6) and many more products for this protein.
Showing 10 out of 58 products:
Graded activation and free energy landscapes of a muscarinic G-protein-coupled M2 receptor has been reported.
With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR (show CHRM3 ELISA Kits)
Results show reduced autonomic nervous system (ANS) activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia.
Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants
Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD (show ARCN1 ELISA Kits) patients.
Inactivation of M2 AChR/NF-kappaB (show NFKB1 ELISA Kits) signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.
CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.
This study demonstrated that CD4 (show CD4 ELISA Kits)+ and CD8 (show CD8A ELISA Kits)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.
The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha subunits in Escherichia coli.
CHRM2 but not CHRM1 (show CHRM1 ELISA Kits) or CHRM3 (show CHRM3 ELISA Kits) polymorphisms are associated with asthma susceptibility in Mexican patients.
The three receptor sets considered (mAChR (show CHRM3 ELISA Kits), AR and TrkB (show NTRK2 ELISA Kits) receptors) intervene in modulating the conditions of the competition between nerve endings.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1 (show GALR1 ELISA Kits), and the CB1 (show CNR1 ELISA Kits) receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD ELISA Kits) muscarinic receptor (show CHRM5 ELISA Kits) subtypes was also analyzed in brain areas involved in anxiety and cognition.
Muscarinic M2 receptors in the circular muscular layer of mouse ileum exert a previously undocumented function in gut (show GUSB ELISA Kits) motility via the regulation of gap junctions
IL-17 (show IL17A ELISA Kits) production in the hearts of M2AChR mice is dependent on P2x7 (show P2RX7 ELISA Kits) expression in dilated cardiomyopathy.
Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS ELISA Kits)-/- males and females, although only males exhibited a urinary phenotype.
These results demonstrate that M2R are dysfunctional and do not affect ACh levels in PRiMA knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.
Data indicate taht m2R-RGS6 (show RGS6 ELISA Kits)-IKACh pathway sets heart rate variability independently from the autonomic input.
M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (show ROCK2 ELISA Kits) (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG (show PRKG1 ELISA Kits) inhibitor H89.
M2 receptor is co-localized with VGLUT2 on intraganglionic laminar endings of esophagus.
Presence of M2 mAChR (show CHRM3 ELISA Kits) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.
cloning, characterization and expression patterns; results suggest that the M2 mAChR (show CHRM3 ELISA Kits) inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia
The M(2) muscarinic receptor (show CHRM5 ELISA Kits) plays a specific role in the initiation of hypoxic bradycardia in fish.
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers.
The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM (show KRIT1 ELISA Kits)-activated plasma membrane-bound PDE1A (show PDE1A ELISA Kits), linked to M(2)AChR.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC ELISA Kits)/protein kinase C (show PKC ELISA Kits) pathway
Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1 (show ADRB1 ELISA Kits)) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
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, Muscarinic acetylcholine receptor M2
, cholinergic receptor muscarinic 2
, muscarinic acetylcholine receptor M2-like
, M2 muscarinic acetylcholine receptor
, cholinergic receptor, muscarinic 2, cardiac
, muscarinic receptor m2
, muscarinic receptor 2