Chromobox Homolog 2 Proteins (CBX2)

CBX2 encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Additionally we are shipping CBX2 Antibodies (87) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBX2 12416 P30658
CBX2 84733 Q14781
Rat CBX2 CBX2 303730  
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Top CBX2 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
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Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg 11 Days
$291.50
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CBX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Chromobox Homolog 2 (CBX2) Interaction Partners

Mouse (Murine) Chromobox Homolog 2 (CBX2) interaction partners

  1. marker of heterochromatin formation produced by PRC2, had minimal effects on the CBX2 condensate formation

  2. the compaction region of CBX2 plays a key role in establishing proper axial patterning, thereby expanding the functional regions of this protein.

  3. We find that the N-terminus of Cbx2 is needed for its recruitment to mitotic chromosomes, whereas the C-terminus is required for its immobilization.

  4. Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.

  5. This study implicates Cbx2 in testis differentiation through regulating Sry gene expression.

  6. Data show that Polycomb repressive complex 2 is necessary to maintain normal levels of OGT and for the correct cellular distribution of O-GlcNAc.

  7. Zfp277 in the transcriptional regulation of the Ink4a/Arf locus and the recruitment of PRC1 to the Ink4a/Arf locus

  8. these results suggest that the binding specificity of Cbx2 protein for methylated histones is regulated by phosphorylation.

  9. murine geminin associates transiently with members of the Hox-repressing polycomb complex, with the chromatin of Hox regulatory DNA elements and with Hox proteins

  10. Polycomb protein M33 controls critical expansion of B- and T-lymphocyte precursors

  11. The Polycomb M33 gene is an essential upstream regulator of Ad4BP/SF1.

  12. We conclude that this amino-acid stretch in M33 acts as the functional nuclear localization signal for this protein

  13. different CBX proteins are recruited to distinct chromatin regions through nonconserved interactions. Metaphase spreads revealed reciprocal patterns of chromosome association by CBX2 and CBX6

  14. Transformations of the axial skeleton are enhanced in compound mutant embryos for the polycomb group gene M33/Cbx2.

Human Chromobox Homolog 2 (CBX2) interaction partners

  1. study indicates a distinct function of the shorter form of CBX2 and by identifying several of its unique targets, can advance our understanding of DSD pathogenesis and ultimately DSD diagnosis and management.

  2. These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes.

  3. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax-group genes and it overexpressed polycomb genes EZH2 and CBX2.

  4. up-regulated in metastatic castration-resistant prostate cancer and elevated expression correlates with poor clinical outcome

  5. CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway.

  6. CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast

  7. This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development.

  8. Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex.

  9. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin

  10. hPc2 serves as a SUMO E3 ligase for cystathionine beta-synthase, increasing the efficiency of sumoylation.

CBX2 Protein Profile

Protein Summary

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with Chromobox Homolog 2 Proteins (CBX2)

  • chromobox 2 (cbx2)
  • chromobox 2 (CBX2)
  • chromobox homolog 2 (Drosophila Pc class) (cbx2)
  • chromobox 2 (Cbx2)
  • chromobox 2 L homeolog (cbx2.L)
  • cbx2 protein
  • cdca6 protein
  • m33 protein
  • MOD2 protein
  • pc protein
  • pc1 protein
  • SRXY5 protein
  • wu:fd20e09 protein
  • zgc:103563 protein

Protein level used designations for Chromobox Homolog 2 Proteins (CBX2)

chromobox homolog 2 , modifier 3 protein , chromobox protein homolog 2-like , chromobox homolog 2 (Pc class homolog, Drosophila) , chromobox protein homolog 2 , M33 polycomb-like protein , hromobox homolog 2 , polycomb , Pc class homolog , cell division cycle associated 6 , modifier 3 , Polycomb homolog Pc1 , chromobox homolog 2 (Pc class homolog)

GENE ID SPECIES
100125497 Oryzias latipes
100410455 Callithrix jacchus
327291 Danio rerio
12416 Mus musculus
84733 Homo sapiens
398110 Xenopus laevis
426248 Gallus gallus
483349 Canis lupus familiaris
303730 Rattus norvegicus
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