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Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines.
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C1orf190 can activate NF-kappaB (show NFKB1 Antibodies), drive production of cytokines, and promote the antigen-presenting function and priming ability of dendritic cells.
found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain
Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity).
chromosome 1 open reading frame 190
, NF-kappa-B activator C1orf190
, leucine repeat adapter protein 35A
, leucine repeat adaptor protein 35a
, NF-kappa-B activator C1orf190 homolog
, adaptor protein LRAP35a