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The protein encoded by CSTF3 is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). Additionally we are shipping Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 3, 77kDa Antibodies (79) and and many more products for this protein.
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Crystal structure of the HAT (half a TPR) domain of murine CstF-77, as well as its C-terminal subdomain.
X77K could be involved in masking of mRNA prior to polyadenylation
Results from a study on gene variability markers in early-stage human embryos shows that CSTF3 is a putative variability marker for the 3-day, 8-cell embryo stage.
Thus, the conserved intronic pA of the CstF-77 gene may function as a sensor for cellular C/P and splicing activities, controlling the homeostasis of CstF-77 and C/P activity and impacting cell proliferation and differentiation.
nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function
The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization.
chimeric human CstF-77/Drosophila suppressor of forked proteins rescue suppressor of forked mutant lethality and mrna 3' end processing in Drosophila
The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
, cleavage stimulation factor subunit 3
, CF-1 77 kDa subunit
, CSTF 77 kDa subunit
, Cleavage stimulation factor 77 kDa subunit
, cleavage stimulation factor subunit 3-like
, cleavage stimulation factor 77 kDa subunit
, cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa, a