Protein Summary

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits\; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

Gene names and symbols associated with F13A1

• coagulation factor XIII A1 chain (F13a1) antibody
• coagulation factor XIII, A1 polypeptide b (f13a1b) antibody
• coagulation factor XIII A chain (F13A1) antibody
• coagulation factor XIII, A1 subunit (F13a1) antibody
• coagulation factor XIII A chain (F13a1) antibody

• 1200014I03Rik antibody
• AI462306 antibody
• F13A antibody
• F13A1 antibody
• wu:fo83d04 antibody
• Show all synonym aliases
• zgc:153334 antibody

Protein level used designations for F13A1

coagulation factor XIII A chain , coagulation factor XIII, A1 subunit , coagulation factor XIIIa , protein-glutamine gamma-glutamyltransferase A chain , transglutaminase A chain , FX111a-87 , fo83d04 , coagulation factor XIII A1 subunit , coagulation factor XIII, A1 polypeptide , blood coagulation factor XIII A1 subunit , coagulation factor XIIIA , Coagulation factor XIII A chain , FSF, A subunit , TGase , bA525O21.1 (coagulation factor XIII, A1 polypeptide) , coagulation factor XIII, A polypeptide , factor XIIIa , fibrin stabilizing factor, A subunit , fibrinoligase , transglutaminase. plasma , Factor XIIIA , coagulation factor XIII, alpha subunit , coagulation factor XIII A chain-like