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Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Additionally we are shipping Collagen, Type III Antibodies (187) and Collagen, Type III Kits (69) and many more products for this protein.
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Thrombin (show F2 Proteins) generation had a limited impact as biomarker of venous thromboembolism.
Polymorphisms of F2, PROC, PROZ, and F13A1 Genes are Associated With Recurrent Spontaneous Abortion in Chinese Han Women.
the prothrombotic activity of FII is the result of a polymorphism and of a missense mutation, whereas that of FV derives only from a polymorphism. The observation that a clotting factor (show F7 Proteins) defect may be associated with both bleeding or venous thrombosis depending on the site of the mutation has caused an extensive reevaluation of the blood clotting mechanism.
Findings provide evidence for a relationship between two genes-three mutations-of the cardiovascular disease (CVD genes panel and recurrent pregnancy loss (RPL). These genotypes include the heterozygous state of the factor II G20210A mutation.
digestion of thrombin (show F2 Proteins) by P. aeruginosa elastase leads to the release of the C-terminal thrombin (show F2 Proteins)-derived peptide FYT21, which inhibits pro-inflammatory responses to several pathogen-associated molecular patterns.
Prothrombin (show F2 Proteins) gene mutation is rare in Budd-Chiari syndrome patients in India.
In HBV-related cirrhosis, the combination of miR (show MLXIP Proteins)-122, AFP (show AFP Proteins) and PIVKA-II enables the identification of patients at higher risk of hepatocellular carcinoma development.
Data, including data using network analysis, suggest that angiotensinogen (AGT (show AGT Proteins)), mitogen-activated protein kinase-14 (MAPK14 (show MAPK14 Proteins)), and prothrombin (show F2 Proteins) (F2) in placental villous tissues are core factors in early embryonic development; these studies involved proteomics and bioinformatics analysis of altered protein expression in placental villous tissue from early recurrent miscarriage patients in comparison to control tissues.
Arg596Gln mutation is a risk factor for Chinese patients with venous thromboembolism due to its moderately decreased clotting activity but strong resistance to antithrombin (show SERPINC1 Proteins) inhibition.
The induction of TG by BXPC3 cells was mainly driven by the TF pathway while TG generation triggered by MCF7 cells was also driven by FXII (show F12 Proteins) activation.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin (show F2 Proteins) generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin (show F2 Proteins)-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin (show F2 Proteins) carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (show BGN Proteins) plays a protective role during the progression of atherosclerosis in ApoE (show APOE Proteins)-deficient mice by inhibiting thrombin (show F2 Proteins) generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (show GP1BA Proteins)-binding and heparin-binding site of thrombin (show F2 Proteins)
thrombin (show F2 Proteins)/PAR-1 (show MARK2 Proteins) interaction regulated MCP-1 (show CPT1B Proteins), TF, MCSF (show CSF1 Proteins) and IL-6 (show IL6 Proteins) production.
Observations illustrate the role of thrombin (show F2 Proteins) as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (show SERPINC1 Proteins) nanoparticle therapeutics.
Thrombin (show F2 Proteins)-PAR1 (show F2R Proteins) signaling, via nitric oxide and EPCR (show PROCR Proteins), promotes hematopoietic stem cell (HSC (show FUT1 Proteins)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin (show F2 Proteins) promotes sustained signaling and inflammatory gene expression through the CDC25 (show CDC25C Proteins) and Ras-associating domains of phospholipase C epsilon (show PLCE1 Proteins).
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
prepro-coagulation factor II
, prothrombin B-chain
, serine protease
, coagulation factor 2