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COL16A1 encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Additionally we are shipping COL16A1 Proteins (3) and and many more products for this protein.
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The NC11 domain of collagen XVI is a potential biomarker for oral squamous cell carcinoma and triggers vasculogenic mimicry via upregulation of endothelial receptors VEGFR1, VEGFR2 and uPAR.
High Collagen XVI expression is associated with invasion of oral squamous cell carcinoma.
collagen XVI plays a decisive role in the interaction of connective tissue cells with their ECM, which is impaired in pathological situations
Gene expression profiles showed that COL16A1 was up-regulated in epidermolysis bullosa subtypes.
Overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 induction, increased Kindlin-1/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype.
Collagen XVI promotes persistence of intestinal subepithelial myofibroblasts in the normal and in the inflamed bowel wall by stabilizing focal adhesion contacts.
Not in banded collagen fibrils in dermis, but is component of specialized fibrillin-1-containing microfibrils. In cartilage matrix not in aggregates with fibrillin-1. Resides in thin, weakly banded collagen fibrils also containing collagens II and XI.
interacts with fibrillin-1 and with fibronectin indicating multiple molecular interactions in which this ubiquitously expressed and versatile fibril-associated collagens with interrupted triple helices-collagen can participate
These results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.
there is a unique alpha1 beta1 integrin-binding site within collagen XVI located close to its C-terminal end
Data show tha collagen XVI is a neural component of the developing and regenerating dorsal root ganglia extracellular matrix.
This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.
procollagen, type XVI, alpha 1
, collagen, type XVI, alpha 1
, alpha 1 type XVI collagen
, collagen alpha-1(XVI) chain-like
, collagen XVI, alpha-1 polypeptide
, collagen alpha-1(XVI) chain
, [a]1 (XVI) collagen
, procollagen type XVI alpha 1