The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene names and symbols associated with CFHR3
complement factor H-related 3 (Cfhr3) antibody
complement factor H related 3 (CFHR3) antibody
Protein level used designations for CFHR3
H factor-like 4
, H factor-like protein 3
, complement factor H-related protein 3