Complement Fragment 3a Proteins (C3a)

Human Complement Fragment 3a (C3a) interaction partners

1. MUC5B promoter variant is associated with higher C3 expression and suggest that the complement system may contribute to the pathogenesis of idiopathic pulmonary fibrosis.

2. Low serum C3 level can estimate severe ANCA-associated vasculitis and predict poor renal outcome in immunosuppressive drug-naive patients at diagnosis.

3. REVIEW: Emerging roles in cancer progression and treatment

4. Products of complement C3 (opsonin iC3b) are loosely deposited on the surface of Chlamydia trachomatis in complement competent serum. Complement competent serum facilitates rapid uptake of bacteria into monocytes however does not influence intracellular survival of C. trachomatis or C. trachomatis-induced cytokine secretion.

5. complement C3 and C4 plays important roles in the development of myeloma bone disease

6. Detection of complement binding activity using both C1q and C3d assays can be a further prognostic marker for predicting antibody mediated rejection and allograft outcome in donor-specific HLA antibodies kidney transplant patients.

7. this study shows that C3a is required for ILC2 function in allergic airway inflammation

8. Patients with decreased complement C3/complement C4 (C3/C4) ratios displayed significantly more severe clinical characteristics and renal pathological features.

9. The present study showed no association between methylation levels of C3 promoter and the risk of CAD. However, the methylation levels might be related to LDL-C levels.

10. Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host major complement components C3, C4, and C5.

11. The pooled ORs for rs551397, rs2274700, rs4151667, rs641153, rs1047286, rs9332739, and rs547154 in the heterozygote model were 0.53, 0.53 , 0.54, 0.48, 1.42, 0.50, and 0.52, respectively. We confirmed the protective role of C2/CFB/CFH polymorphisms in the development of Age-Related Macular Degeneration (AMD), and showed single nucleotide polymorphism in C3 was a high-risk factor for AMD

12. Evasion of C3b deposition at division septa and lateral amplification underneath the capsule requires localization of the FH-binding protein PspC at division sites.

13. Clinical Manifestation of Patients With Atypical Hemolytic Uremic Syndrome With the C3 p.I1157T Variation in the Kinki Region of Japan.

14. In our meta-analysis, C3 genetic polymorphisms unveiled a positive effect on the risk of advanced age-related macular degeneration, especially in Caucasians

15. Case Report: recurrent proliferative glomerulonephritis with persistent isolated C3 deposition.

16. A phage Ab against C3b that inhibited the alternative complement pathway, but not the classical pathway, was described in 2009. Studies using this Ab in a variety of assays have now demonstrated that it acts primarily by inhibiting tickover, thereby confirming that tickover really exists.

17. Anti-HLA class I and class II C3d-binding donor-specific antibodies carried a twofold and 1.5-fold increased risk of kidney graft loss, respectively.

18. Study shows no significant association of the C3 gene with uveitis, suggesting C3 confers either no or limited risk for uveitis susceptibility.

19. Here we have shown for the first time, that ligand- or insulin-mediated activation of PPARgamma in human hepatoma cell line HepG2 causes the downregulation of C3 gene expression and protein secretion

20. Single Nucleotide Polymorphism rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.