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CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.
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CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival.
Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf (show RAF1 Proteins) protein (RAF (show RAF1 Proteins)) and c-akt (show AKT1 Proteins) protein (AKT (show AKT1 Proteins)) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner.
The findings reveal SAM (show TTN Proteins) domain-dependent oligomerization by AKT (show AKT1 Proteins) as a switch for CNK1 activation.
tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.
CNK1 mediates ephrinB1 (show EFNB1 Proteins) signaling that promotes cell migration through RhoA (show RHOA Proteins) and JNK (show MAPK8 Proteins) activity.
Studies indicate that CNK1-driven proliferation relies on Akt (show AKT1 Proteins)-dependent phosphorylation and inactivation of FoxO (show FOXO3 Proteins) proteins.
These findings identify CNK1 as a new positive regulator of insulin (show INS Proteins) signaling.
Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.
CNK1 promotes oncogenic signalling through Akt (show AKT1 Proteins) in breast cancer cell lines and tumours.
hCNK1 associates with Rhophilin (show RHPN1 Proteins) and RalGDS (show RALGDS Proteins), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (show HOMER1 Proteins) to mediate cross talk between the two pathways
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.
connector enhancer of kinase suppressor of ras 1
, connector enhancer of kinase suppressor of Ras 1
, connector enhancer of kinase suppressor of ras 1-like
, CNK homolog protein 1
, connector enhancer of KSR 1