Connector Enhancer of Kinase Suppressor of Ras 1 Proteins (CNKSR1)

CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target.

list all proteins Gene Name GeneID UniProt
Human CNKSR1 CNKSR1 10256 Q969H4
Mouse CNKSR1 CNKSR1 194231  
Rat CNKSR1 CNKSR1 298545  
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
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More Proteins for Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Interaction Partners

Human Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) interaction partners

  1. CNKSR1 expression is increased in pancreatic cancer specimens and was found to be an independent prognostic marker of overall survival.

  2. Data indicate connector enhancer of kinase suppressor of Ras 1 protein (CNK1) as a molecular platform that controls c-raf (show RAF1 Proteins) protein (RAF (show RAF1 Proteins)) and c-akt (show AKT1 Proteins) protein (AKT (show AKT1 Proteins)) signalling and determines cell fate decisions in a cell type- and cell stage-dependent manner.

  3. The findings reveal SAM (show TTN Proteins) domain-dependent oligomerization by AKT (show AKT1 Proteins) as a switch for CNK1 activation.

  4. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.

  5. CNK1 mediates ephrinB1 (show EFNB1 Proteins) signaling that promotes cell migration through RhoA (show RHOA Proteins) and JNK (show MAPK8 Proteins) activity.

  6. Studies indicate that CNK1-driven proliferation relies on Akt (show AKT1 Proteins)-dependent phosphorylation and inactivation of FoxO (show FOXO3 Proteins) proteins.

  7. These findings identify CNK1 as a new positive regulator of insulin (show INS Proteins) signaling.

  8. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.

  9. CNK1 promotes oncogenic signalling through Akt (show AKT1 Proteins) in breast cancer cell lines and tumours.

  10. hCNK1 associates with Rhophilin (show RHPN1 Proteins) and RalGDS (show RALGDS Proteins), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (show HOMER1 Proteins) to mediate cross talk between the two pathways

Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Protein Profile

Protein Summary

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.

Gene names and symbols associated with CNKSR1

  • connector enhancer of kinase suppressor of Ras 1 (cnksr1)
  • connector enhancer of kinase suppressor of Ras 1 (CNKSR1)
  • connector enhancer of kinase suppressor of Ras 1 L homeolog (cnksr1.L)
  • connector enhancer of kinase suppressor of Ras 1 (Cnksr1)
  • BC037758 protein
  • CNK protein
  • CNK1 protein
  • CNKSR1 protein
  • KSR protein
  • zgc:77200 protein

Protein level used designations for CNKSR1

connector enhancer of kinase suppressor of ras 1 , connector enhancer of kinase suppressor of Ras 1 , connector enhancer of kinase suppressor of ras 1-like , CNK homolog protein 1 , connector enhancer of KSR 1 , hCNK1

GENE ID SPECIES
402957 Danio rerio
469241 Pan troglodytes
100015613 Monodelphis domestica
100144653 Xenopus (Silurana) tropicalis
100158310 Xenopus laevis
100462050 Pongo abelii
100476443 Ailuropoda melanoleuca
10256 Homo sapiens
487359 Canis lupus familiaris
100624309 Sus scrofa
194231 Mus musculus
298545 Rattus norvegicus
617552 Bos taurus
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