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May play a role during embryogenesis (By similarity). Additionally we are shipping Craniofacial Development Protein 1 Antibodies (78) and Craniofacial Development Protein 1 Proteins (9) and many more products for this protein.
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The results show that CFDP1 is an essential protein required for proper development and provide the first experimental evidence showing that in vertebrates it actively participates in the morphogenesis of craniofacial territories.
Our findings provide new insight into the chromatin functions and mechanisms of the CFDP1 protein and contribute to our understanding of the link between epigenetic regulation and the onset of human complex developmental disorders.
Overall, these findings highlight unanticipated evidences suggesting that homodimerization mediated by the BCNT domain is integral to the chromatin functions of BCNT proteins.
Bcnt/Cfdp1 is acetylated in vitro by CREB-binding protein (CBP (show CREBBP ELISA Kits)) and four lysine residues including Lys (show LYZ ELISA Kits)(268) in BCNT-C are also acetylated in vivo, revealing a protein regulated at multiple levels.
This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of carotid intima-media thickness and coronary artery disease risk.
Cfdp1 contains consensus TFII-I binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.
These results provide a basis for our understanding of the specific regulation of the cp27 gene in the NF-Y-mediated gene transcription network.
CP27 affects viability, proliferation, attachment and gene expression in embryonic fibroblasts.
May play a role during embryogenesis (By similarity).
craniofacial development protein 1
, centromere protein 29
, phosphoprotein (Bucentaur)
, 27 kDa craniofacial protein
, h-type BCNT protein
, human-type Bcnt
, p97 homologous protein