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Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009].. Additionally we are shipping Cyclin Y Antibodies (50) and Cyclin Y Kits (17) and many more products for this protein.
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CycY/Eip63E form a cyclin (show PCNA Proteins)/Cdk (show CDK4 Proteins) complex that is essential for several developmental processes.
findings revealed an unrecognized role of Caprin-2 (show CAPRIN2 Proteins) in facilitating LRP5 (show LRP5 Proteins)/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14 (show CDK14 Proteins), Cyclin Y, and LRP5 (show LRP5 Proteins)/6.
we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC
CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc (show MYC Proteins), cyclin D1 (show CCND1 Proteins), PFTK1 (show CDK14 Proteins), ki67 (show MKI67 Proteins), and OGT (show OGT Proteins) protein expressions in xenograft tumor tissues.
Activation of PCTAIRE-1 (show CDK16 Proteins) is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3 (show YWHAQ Proteins).
Our findings highlight a PFTK1 (show CDK14 Proteins)-CCNY complex in activating noncanonical Wnt (show WNT2 Proteins) signaling in HCC (show FAM126A Proteins) cells.
Human cyclin Y (CCNY) is a phosphoprotein in vivo and phosphorylation of CCNY by CDK14 (show CDK14 Proteins) triggers its ubiquitination and degradation.
Cyclin Y regulates the expression and membrane trafficing of PCTAIRE (show CDK16 Proteins) kinases (PCTK). (Review)
CCNY (show CDK16 Proteins)binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site.
these results validated the role of CCNY as a clinically relevant human oncoprotein
CCNY might play an important role in glioma tumorigenisis.
Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
these results provide a new link between CCNY and lipid metabolism in mice.
CDK16 (show CDK16 Proteins) isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2\; MIM 116940) (Li et al., 2009
, drosophila cyclin Y
, cyclin box protein 1
, cyclin fold protein 1
, cyclin-box carrying protein 1