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The protein encoded by CDK13 is a member of the cyclin-dependent serine/threonine protein kinase family. Additionally we are shipping CDK13 Antibodies (41) and many more products for this protein.
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heterozygous, likely dominant negative mutations affecting the protein kinase (show CDK7 Proteins) domain of the CDK13 gene result in a recognisable, syndromic form of intellectual disability, with or without congenital heart disease.
Detailed phenotypic and molecular characterisation of 9 individuals with pathogenic variants in CDK13 is provided. Two individuals had novel CDK13 variants (p.Asn842Asp, p.Lys734Glu), while the remaining seven unrelated individuals had a recurrent, previously published p.Asn842Ser variant.
CDK13 gene is amplified in different types of cancer indicate that this kinase can contribute to cancer development in human.
CDK12 (show CRKRS Proteins) and CDK13 losses in HCT116 cells preferentially affect expression of DNA damage response.
High CDK13 expression is associated with pancreatic cancer.
Coincidently amplified CDK13, GMNN (show GMNN Proteins), and CENPF (show CENPF Proteins) genes can play a role as common cancer-driver genes in human cancers.
CDK13 interacts with cyclin K (show CCNK Proteins), and is required for self-renewal in ES cells.
Data demonstrate that CDC2L5 is located in the nucleoplasm, where it directly interacts with the ASF/SF2 (show SRSF1 Proteins)-associated protein p32 (show C1QBP Proteins), a protein involved in splicing regulation.
The findings of this study suggest that Cdk12 (show CRKRS Proteins) and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 (show CDK5 Proteins) expression.
The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.
cell division cycle 2-like 5 (cholinesterase-related cell division controller)
, cholinesterase-related cell division controller
, cyclin-dependent kinase 13
, CDC2-related protein kinase 5
, cell division cycle 2-like protein kinase 5
, cell division protein kinase 13