Cystatin E/M (CST6) ELISA Kits

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Additionally we are shipping CST6 Antibodies (101) and CST6 Proteins (16) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CST6 1474 Q15828
Anti-Mouse CST6 CST6 73720  
Anti-Rat CST6 CST6 171096  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.064 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days

More ELISA Kits for CST6 Interaction Partners

Human Cystatin E/M (CST6) interaction partners

  1. High CST6 expression is associated with lymph-node metastasis in Triple-Negative Breast Cancer.

  2. Data suggest that melanoma cells internalize/absorb cystatin C from culture media, leading to increased intracellular cystatin C levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain activity is pronounced.

  3. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB.

  4. Low CST6 expression is associated with breast cancer.

  5. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs.

  6. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals.

  7. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain activity.

  8. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival.

  9. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor, progesterone receptor, and HER4 in tumor tissues was found

  10. the level of cystatin E/M regulates legumain activity and hence the invasive potential of human melanoma cells

  11. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis

  12. Cystatin M suppresses the malignant phenotype of MDA-MB-435S cells.

  13. Complete loss of expression of cystatin M was observed in two of three stage IV breast cancer patients. Immunohistochemical studies confirmed that expression of cystatin M in IDCs was partially or completely lost.

  14. This study thus provides the first evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression.

  15. Identification of CTSV & CTSL as targets for cystatin M/E, their (co)-expression in the stratum granulosum of skin, and activity of CTSL toward transglutaminase 3 strongly imply an important role for them in the differentiation process of human epidermis.

  16. Tumors displaying CST6 gene methylation, display methylation in both ductal carcinoma in situ and invasive breast carcinoma lesions and reduced expression of cystatin M in these tumors was confirmed by immunohistochemistry

  17. strong link between CST6 promoter hypermethylation and loss of CST6 expression in breast cancer cell lines

  18. Cystatin M may encode a novel epigenetically inactivated candidate tumor suppressor gene.

  19. Methylation-dependent epigenetic silencing of CST6 represents an important mechanism for loss of CST6 during breast tumorigenesis and/or progression to metastasis.

  20. cystatin E/M is a cervical cancer suppressor gene and that the gene is inactivated by somatic mutations and promoter hypermethylation.

Mouse (Murine) Cystatin E/M (CST6) interaction partners

  1. Using quenched activity-based probes, we identified mouse cathepsin B (CtsB), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6

  2. conclude that a tightly regulated balance between cathepsin L and cystatin M/E is essential for tissue integrity in epidermis, hair follicles, and corneal epithelium

  3. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]

CST6 Antigen Profile

Antigen Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Gene names and symbols associated with Cystatin E/M (CST6) ELISA Kits

  • cystatin E/M (CST6) antibody
  • cystatin E/M (Cst6) antibody
  • 1110017E11Rik antibody
  • CST6 antibody
  • ichq antibody
  • N28197 antibody

Protein level used designations for Cystatin E/M (CST6) ELISA Kits

cystatin E/M , cystatin M , cystatin-M , cystatin 6 , cystatin M/E , cystatin-6 , cystatin-E , cysteine proteinase inhibitor , harlequin ichthyosis , harlequin ichthysosis , cystatin N

466668 Pan troglodytes
503685 Bos taurus
714999 Macaca mulatta
1474 Homo sapiens
483719 Canis lupus familiaris
73720 Mus musculus
171096 Rattus norvegicus
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