Cystatin F (Leukocystatin) (CST7) ELISA Kits

Human Cystatin F (Leukocystatin) (CST7) interaction partners

1. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells.

2. Transgenic cystatin F is expressed in model mice only during demyelination; in chronic demyelination, remyelinating ability is lost.

3. cystatin F is an intracellular cysteine peptidase inhibitor with readily regulated expression

4. CST7 is secreted, but artificial modification of its C-terminus can induce its endocytic targeting.

5. Cystatin F was not colocalized with cystatin C (show CST3 ELISA Kits) shich suggests distinct functions for these two cysteine protease (show CTSB ELISA Kits) inhibitors in U937 cells.

6. analysis of reduction-dependent activation of human cystatin F

7. Data demonstrate the addition of N-linked sugars to an Asn-X-Cys (show DNAJC5 ELISA Kits) motif in cystatin F and suggest that the mannose 6-phosphate sorting machinery is used to divert cystatin F from the secretory pathway and to mediate its uptake from extracellular pools.

Mouse (Murine) Cystatin F (Leukocystatin) (CST7) interaction partners

1. High CST7 expression is associated with Alzheimer's disease.

2. Our results validate cystatin F as a useful biomarker of early pathogenesis in experimental models of prion (show PRNP ELISA Kits) disease, and point to unexpected species-specific differences in the transcriptional responses to prion (show PRNP ELISA Kits) infections.

3. During the active remyelinating phase, both CysF knockdown (CysFKD) and microglial-selective CatC (show CTSC ELISA Kits) overexpression (CatCOE) showed a worsening of the demyelination in Plp (show C3 ELISA Kits)(4e/-) transgenic mice. Conversely, during the chronic demyelinating phase, CatC (show CTSC ELISA Kits) knockdown (CatCKD) ameliorated the demyelination. Our results suggest that the balance between CatC (show CTSC ELISA Kits) and CysF expression controls the demyelination and remyelination process.

4. The cystatin F expression in the activated microglia is closely associated with the effect of the A2A receptors, which may be related to the neuroinflammatory responses occurring during the pathological process.

5. an inhibitory activity other than cystatin F quenches CatL activity in activated macrophages

6. Expression of cystatin F indicates ongoing demyelination and remyelination; absence of cystatin F expression indicates cessation of remyelination in the demyelinating area.

7. The embryo's cystatin C (show CST3 ELISA Kits) and F expression functions as a protective mechanism against the maternal proteinase cathepsin S (show CTSS ELISA Kits).