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The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Additionally we are shipping Cystatin SN Antibodies (68) and Cystatin SN Proteins (11) and many more products for this protein.
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Human CST1 ELISA Kit for Sandwich ELISA - ABIN857218
Dsamou, Morzel, Le Corre, Séverin, Chagnon: Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells. in Archives of oral biology 2013
Show all 4 Pubmed References
Results revealed that CST1 expression was upregulated in colon cancer (CC) compared with normal tissues and contributed to CC cell proliferation.
High CST1 expression is negatively correlated with survival of breast cancer patients. CST1 promotes cell proliferation, clone formation, and metastasis in breast cancer cells. CST1 is a novel potential prognostic biomarker and therapeutic target for breast cancer.
this results identified cystatin 1 as a biomarker in patients with seasonal allergic rhinitis
These results indicate that CST1-mediated extracellular CatB activity enhances tumor development by preventing cellular senescence.
interactions of human family 1 & 2 cystatins with cathepsin L1
high expression of Cystatin SN is a significant prognostic indicator of a higher rate of recurrence, metastatic risk, and poor survival in patients with surgically resected NSCLCs.
In conclusion, our data suggest that CST1 might contribute to the proliferation of pancreatic cancer cells and could be a potential biomarker for the early detection of pancreatic cancer.
CST1 may contribute to inactivation of protease allergens and help re-establish homeostasis of the nasal membranes.
CST1 expression at both the messenger RNA and protein levels was barely detected in control cells, which included early passage proliferating, quiescent, or immortal human fibroblasts
Murine monoclonal antibodies were made which can distinguish between CST1 and CST2.
CST1 might be highly involved in gastric tumorigenesis and regulate the proteolytic activity of cysteine proteases.
Identification of Cystatin SN as a novel tumor marker for colorectal cancer.
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.
, cystatin SA-I
, cysteine proteinase inhibitor, type 2 family
, salivary cystatin-SA-1